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Pilot-scale freeze dryers with ice condenser capacities between 6 and 12 kg are specially designed for drying processes similar to large-scale production units. Prefreezing and drying will be realized on liquid temperature controlled shelves inside the separate drying chamber (double-chamber-system). Due to the temperature control of the stainless steel shelves (via a synthetic heat-transfer medium), these pilot systems fulfil the highest standards of the pharmaceutical and biotech industries. The CHRIST pilot-scale freeze dryers can be upgrated or modified to meet the individual requirements for process optimization and scale-up, e.g. with a comprehensive and flexible measurement- and control-system (e. g. lyo-resistance-control, weighing-system, process monitoring). If necessary, a decontamination with H2O2 is possible as well as an integration into isolator systems (glove-box).
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FTS LyoStar II is the pinnacle of R&D freeze dryer engineering. Designed and built like a production freeze drier, yet the size of a R&D Pilot model. The LyoStar II with breakthrough “Smart Freeze-Dryer™ Technology” will revolutionize the way development scientists generate freeze-drying cycles.
The LyoStar II has everything that you would expect, superior shelf mapping, fast shelf freezing, stoppering for vials, easy to use sample thief, and incredible software which reduces the average R&D cycle time from 64 days to 13.
SMART Freeze-Dryer Technology is a patented system that puts
the experience of the world’s top lyophilisation scientists into an
easy-to-use cycle development tool. Developed exclusively with
leading academics SMART Freeze-Dryer Technology relates to the automated process control of using manometric temperature measurement and is designed to eliminate the trial-and-error approach normally involved in developing new lyophilization cycles. It enables experts and novices alike to develop new cycles quickly, while also ensuring that those cycles are elegant and efficient. The SMART tools provide instant feedback on important product data - such as product resistance, heat flow, and product thickness — that was previously unavailable.
• Shelf pull-down rate from ambient to -40ºC in less than 25 minutes
• Temperature resolution in 0.1ºC increments
• Powerful scroll compressors with only three moving parts (with two-year warranty)
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The freeze drying pilot plant RAY 1 is used in the food and beverage industries for small-scale production of market samples and for pilot testing of new products prior to full-scale production. The RAY 1 also features easy cleaning and maintenance.
The RAYTM 1 plant is also used in bacterial and pharmaceutical applications.
The pilot plant RAYTM 1 is operated via a PC control system. Parameters are monitored and stored during the freeze drying process to provide full documentation of the process. This makes it possible to repeat the test with the same freeze drying characteristics.
Modem for remote control or troubleshooting can be integrated in the PC system.
Test runs with the RAYTM 1 provide excellent data for scaling up to industrial production, either in one of the Atlas RAYTM batch freeze dryers or in a CONRADTM continuous freeze drying plant.
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