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The new PHI TRIFT V nanoTOF surface analysis instrument is the next generation of PHI’s highly successful line of TOF-SIMS instruments which utilize the patented TRIFT analyzer. Several significant improvements have been introduced with the nanoTOF. The superior performance TRIFT analyzer has been combined with a revolutionary new sample handling platform. This innovative new sample handling platform was designed from the ground up specifically for TOF-SIMS, adding the flexibility needed to accommodate samples with complex geometries. In addition, improvements have been made in charge compensation and ion gun performance.
Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) provides sub-micron elemental, chemical, and molecular characterization and imaging of solid surfaces and thin films for products such as semiconductors, hard disk drives, polymers, paint and other surface coatings. Manufacturing companies in the chemical, semiconductor and pharmaceutical industries can use the nanoTOF to improve product performance, conduct failure analysis and manage process control. Time-of-Flight SIMS surface analysis instruments differ from Dynamic SIMS instruments in that they can analyze the outermost one or two mono-layers of a sample while preserving molecular information.
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Innovative MALDI-TOF and TOF/TOF technology for reliable and detailed protein characterization, high resolution MALDI imaging and validated biomarker discovery. Patented smartbeam™ laser technology is a must for MALDI Molecular Imaging and gives access to superior performance in any Proteomics project.
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Superior Q-TOF performance for greater analytical confidence
Using proprietary True Hi-Def TOF technology, Agilent’s 6520 and 6530 bring an unrivaled combination of mass accuracy and resolution, sensitivity, acquisition speed, and in-spectrum dynamic range to your toughest research challenges. The new Agilent 6530 Accurate-Mass Q-TOF LC/MS with Agilent Jet Stream thermal gradient focusing technology increases sensitivity by a further 5X for even greater analytical confidence. All 6500 Series instruments feature the powerful, compound-centric MassHunter Workstation software with its unsurpassed data mining and qualitative and quantitative data analysis capabilities.
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The micrOTOF™ provides powerful exact mass measurements in an easy-to-use benchtop package. Featuring excellent mass resolution and mass accuracy in combination with true isotopic pattern, micrOTOF is the perfect choice for straight-forward formula determination of small molecules, quality control of intact proteins, and metabolic studies.
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Mass Spectrometry (MS) is one of the fastest-growing areas in analytical instrumentation. Magnetic sector and time-of-flight mass spectrometers (manufactured by JEOL) have very high stability, sensitivity, and resolution. These instruments are used in both quantitative and qualitative analysis, including high-resolution accurate mass measurements for the determination of elemental compositions. The use of mass spectrometry in support of synthetic, organic, and pharmaceutical chemistry is well established. However, mass spectrometry is also used in materials science, environmental research, and forensic chemistry. It has also evolved into one of the core methods used in biotechnology.
JEOL manufactures a wide range of magnetic sector mass spectrometers ranging from small bench top double-focusing magnetic sector mass spectrometers to larger tandem and hybrid mass spectrometers. JEOL also offers the new cost-effective high-performance AccuTOF™ API-TOF LC/MS system for qualitative and quantitative analysis.
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The AXIMA series of MALDI TOF Mass Spectrometers
Drawing on the innovative technology developed by Kratos Analytical, the AXIMA series of MALDI TOF Mass spectrometers offers powerful performance for a diverse range of high throughput biochemical applications:
- Proteomics
- Combinatorial chemistry
- Micro-satellite DNA
- SNP analysis
All systems offer the INTELLIMARQUE™ functionality which allows fully-automated data-dependent PMF/PSD proteomics experiments.
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The 4800 Plus MALDI TOF/TOF™ Analyzer is the next generation of tandem time-of-flight MS/MS systems, providing the highest level of protein coverage, throughput, and confidence in quantitative proteomic analysis. The analyzer combines all of the advantages of MALDI in a flexible, easy-to-use, ultra-high-performance mass spectrometer with all the advanced capabilities of ProteinPilot™ v2.0 software.
- Ideal system for protein biomarker discovery, providing simultaneous identification and quantitation of up to 8 samples at a time (8-plex workflow) using iTRAQ™ Reagents.
- Fully supports LC MALDI workflows, allowing you to mass analyze without the time constraints of LC.
- Compatible with ProteinPilot v2.0 software for increased protein coverage and confidence in identification and quantitation results.
- OptiBeam™ on-axis laser provides ten times greater sensitivity to identify and quantitate low-abundance proteins in complex biological samples.
- High-resolution precursor ion selection, enabled by the QuanTIS™ precursor selector, lets you detect and identify peptides that other systems miss and makes it easier for you to interpret your data by simplifying MS/MS spectra.
- Simple experiment setup and fast mass analysis maximizes laboratory productivity.
- High-energy, information-rich fragmentation patterns unavailable on other instrument platforms enable you to analyze carbohydrates, lipids, and other biological components.
- Improved on-board computing capabilities handles large scale protein discovery studies with faster processing and automated data backup.
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The well-known Bruker Daltonics "FLEX" series stands for maximum performance and reliability, providing:
Superior performance characteristics
Maximum flexibility and scalability
Highly automated operation
Seamless interface with the biological lab due to MALDI targets in MTP (or MTP compatible) format
Proprietary AnchorChip™ MALDI target technology
Easy-to-use Compass software
Maximum up-time and comprehensive service concept
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MALDI SYNAPT HDMS
A dual ionization mass spectrometer featuring MALDI and atmospheric pressure ionization. The system is operable in both time-of-flight (TOF) and ion-mobility/TOF modes.
Features:
- Triwave™ Technology, which provides access to the unique benefits of Ion Mobility Spectrometry (IMS)
- Time-aligned parallel (TAP) fragmentation for first- and second-generation fragmentation structural information in a single experiment
- Rapid, exchangeable MALDI/API sources
- High-duty cycle (HDC) mode for enhanced sensitivity over a wide mass range
- Integrates with the nanoACQUITY UPLC® System and the CTC PAL MALDI Spotter/Fraction Collector, so you can perform off-line nanoscale separations with minimized sample complexity and dynamic range issues
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