Solid phase extraction (SPE) is an increasingly useful technique designed for rapid sample preparation and purification for chromatographic or other analyses. Solid phase extraction (SPE) is a chromatographic separation technique utilized to remove solid or semi-solid compounds from a mixture in solution. Samples are concentrated and purified enabling downstream use by MS, GC, LC-MS, HPLC or other analytical methods. Solid phase extraction (SPE) uses the affinity of dissolved or suspended solutes in the liquid (mobile) phase for the solid (stationary) phase, through which the solution is passed to separate the mixture into desirable components.
