Differential scanning calorimeter (DSC)
VP-DSC MicroCal LCC

The VP-DSC is the most sensitive, easy to use differential scanning calorimeter to study samples in solution. Providing fast, accurate transition midpoint (Tm) determination, the VP-DSC has revolutionized the study of liquid biopharmaceutical formulations by reducing the time and cost of stability testing. In addition, a complete thermodynamic profile is generated to understand the factors that affect conformation and stability.

The VP-DSC is controlled by an intelligent user interface (VPViewer™ software) and data analysis is performed with Origin®, a market-leading data analysis package.

VP-DSC features:

- Active cell volume ~ 0.5 ml.
- Non-reactive Tantalum 61™ cells for excellent chemical resistance.
- Fixed-in-place cells for reproducible ultrasensitive performance with low maintenance.
- Operating temperature range of -10ºC to +130ºC.
- Peltier element for precise temperature control.
- User selectable temperature scan rates (0ºC to 90ºC per hour upscans) and range for application versatility.
- Unparalleled sensitivity and reproducibility (Figure 1).
- Three user selectable response times (US Patent #5,967,659) for maximum performance.
- Allows studies of fast or slow transition processes.
- Self-contained pressurizing system (0-45 psi) for studying solutions above their boiling point.
- Includes ThermoVac® sample preparation and cleaning device.
- Pressure Perturbation Calorimetry accessory available for the determination of partial specific volumes.