From Sample to Knowledge by Deeper Metabolomics Insights
The metabolome consists of an extremely complex mixture of small molecules covering a wide dynamic range. As the number of detectable substances continues to grow to include mammalian, microbial, and plant-based endogenous and exogenous metabolites, identification is essential if you want to fully understand the biological context of metabolomic data.
Therefore, the annotation of previously described known target metabolites, known as dereplication, becomes critical and it must be both automatic and conclusive.
Mass spectral libraries containing relevant endogenous and exogenous metabolites enable you to match to experimental MS/MS spectra for automatic dereplication.
The Bruker MetaboBASE Personal Library, generated in collaboration with Professor Gary Siuzdak at the Scripps Center for Metabolomics in La Jolla, California, USA, contains the MS/MS spectra of over 13,000 compounds. All of the spectra were acquired from Bruker QTOF systems.
By comparing high-resolution, accurate mass (HRAM) MS/MS data acquired on your Bruker QTOF instruments with a spectral library on a local PC, the Bruker MetaboBASE Personal Library allows the private, automated and positive identification of known compounds.