Fully-automatic filling machine

syringesyringefor the pharmaceutical industry

Overview
Syringe filling machines for sterile injectable production, covering compact systems for clinical batches to fully automated high-throughput lines. Designed to support Annex 1 compliance and deliver aseptic, reproducible filling with high dosing precision for sensitive biologics and vaccines.

Applications and advantages
Compatible with ready-to-use (RTU) packaging and standard pre-sterilised syringes as well as special primary packaging. Nest processing allows gentle handling of sensitive items, reduces breakage and product loss, and is suitable for start-ups, CDMOs, biotech firms and global pharmaceutical manufacturers.

Key capabilities

• RTU nest processing for safe, efficient handling of pre-sterilised syringes
• Modular, scalable designs enabling customization to production requirements
• Wide dosing range for low- to high-viscosity formulations
• Designs focused on aseptic safety and process integrity (Annex 1-aligned)

Features for safe and reliable filling

• NTT process (No‑Touch Transfer): GMP‑compliant introduction of pre-sterilised packaging in double bags into the class A area, avoiding extra disinfection or bio-decontamination steps; aligned with EU GMP Annex 1 and ICH Q9 principles.
• Dosing systems: rotary piston pump, peristaltic pump, time‑pressure dosing; optional vacuum‑assisted filling and closing; adjustable gas flushing during filling and capping.
• IPC process: automatic statistical in‑process control performing continuous checks on dosing quantities with automatic correction for under/overdosing.
• Process reliability: integrated camera inspection for stopper height and automatic ejection of incorrectly positioned items to minimise manual intervention.

Operational flexibility
Modular configuration and multiple dosing technologies permit adaptation to different formulations and throughput requirements while maintaining stable, controlled conditions throughout filling and closing to ensure reproducible, regulatory‑compliant output.

Characteristics / technical specifications

• Performance: up to 60,000 syringes per hour
• Processing range: 0.5 - 50 ml per syringe
• RTU nest processing supported for gentle handling
• Dosing options: rotary piston pump, peristaltic pump, time‑pressure dosing
• Optional aids: vacuum‑assisted filling/closing, adjustable gas flushing
• Quality controls: automatic IPC with statistical control and camera inspection for stopper height
• Design: modular and scalable; aimed at Annex 1 compliance