Automatic preparation system

in-linecleaning

Overview Inline conditioning replaces time-consuming batch buffer preparation by producing conditioned buffer on demand directly in the process line. This approach reduces the need for large holding tanks, lowers CIP agent and cleaning-water consumption, and supports increasing downstream chromatography and ultrafiltration capacity in biopharmaceutical manufacturing.

Applications

• Monoclonal antibody downstream processing
• Vaccine production
• Antibiotics manufacturing
• Insulin production
• Recombinant protein processes
• Blood product purification

Product Features

• Optimizes buffer preparation method and eliminates large batch tanks
• Reduces footprint of buffer preparation and storage areas
• Lowers consumption of CIP cleaning agents and cleaning water
• Enables faster preparation, reducing dosing time
• Simplifies scale-up and expansion of production capacity
• Reduces fixed capital and expansion investment needs
• Decreases labor effort for operation and maintenance
• High-precision preparation: conductivity ±0.5 mS/cm, pH control within ±0.2
• Stabilization time typically within 2 minutes

Technical characteristics / specifications

• System type: inline conditioning / dilution system for buffer preparation
• Primary benefits: reduced footprint, reduced CIP agent and cleaning-water usage
• Operational advantages: on-demand buffer production, faster dosing, easier scale-up
• Precision: conductivity ±0.5 mS/cm
• Precision: pH control within ±0.2
• Stabilization time: within 2 minutes (typical)
• Typical downstream uses: buffer supply for chromatography and ultrafiltration in biopharmaceutical processes