Mass spectrometer LCMS-8065XE

quadrupoleQMSMS/MS

Overview
The LCMS-8065XE is a flagship triple-quadrupole LC-MS/MS mass spectrometer from Shimadzu, designed for high-sensitivity quantitative analysis in complex matrices. It combines the StreamFocus ion source, IonFocus technology and the UFsweeper IV collision cell to concentrate ions for trace-level detection while maintaining robustness and throughput.

Key benefits

• Evolved StreamFocus ionization improves ion intake and reduces droplet dispersion.
• Efficient High-throughput design with lower gas consumption and reduced running costs.
• Exact Enhanced sensitivity and accuracy for trace-level quantitation in complex matrices.

Core technologies and performance
The StreamFocus ESI probe uses a low-diffusion nebulizer nozzle to reduce droplet dispersion and increase ion intake. The IonFocus unit optimizes ion transmission by focusing target ions and excluding neutral contaminants. The UFsweeper IV collision cell increases ion throughput with a larger entrance lens diameter and additional lenses, improving transmission and sensitivity.

Ultra-fast and high-sensitivity applications
Advanced UF technologies enable ultra-fast acquisition and high sensitivity for quantitative LC-MS/MS, demonstrated for PFAS trace analysis (example: part-per-trillion detection of a 1 ng/L mixed PFAS standard). The system supports reliable quantitation in complex matrices and stable high-throughput workflows.

Robustness, uptime and maintenance
Engineered for easy maintenance: the desolvation line (DL) and ESI capillary are quick to replace; the DL can be replaced without breaking vacuum to minimize downtime. Long-term durability is shown by retaining over 85% of initial response after 10,000 consecutive injections of treated wastewater.

Workflow, automation and software
Automation and software accelerate method development and routine analysis: LabSolutions Connect MRM automates MRM optimization; LabSolutions Insight supports dynamic data review; PeakIntelligence provides AI-driven peak detection and robust integration; PERFORMANCE CONCIERGE automates tuning and diagnostics.

Sustainability and efficiency
The LCMS-8065XE includes an ecology mode that can automatically shut down after inactivity, reducing electricity consumption by about 31%. When paired with Nexera UHPLC systems, it enables ultra-fast analysis that reduces solvent, gas and electricity consumption.

Application highlights
Designed for sensitive PFAS, food safety, clinical and pharmaceutical quantitative analyses. Available application notes demonstrate ultra-high sensitivity PFAS analysis in drinking water and chicken tissue compliant with relevant methods.

Specifications

• Model: LCMS-8065XE
• Manufacturer / Brand: Shimadzu
• Instrument type: Triple-quadrupole liquid chromatograph–mass spectrometer (LC-MS/MS)
• Ion source: StreamFocus ESI probe (low-diffusion nebulizer nozzle)
• Ion transmission: IonFocus unit to focus target ions and exclude neutral contaminants
• Collision cell: UFsweeper IV (increased entrance lens diameter and additional lenses)
• Sensitivity: Trace-level detection (example: 1 ng/L PFAS mixed standard)
• Robustness: Retains >85% initial response after 10,000 consecutive injections in challenging matrices (treated wastewater)
• Maintenance: Replaceable desolvation line (DL) and ESI capillary; DL replaceable without breaking vacuum
• Automation: PERFORMANCE CONCIERGE automatic tuning; LabSolutions Connect MRM for automated MRM optimization
• Data software: LabSolutions Insight for review; PeakIntelligence for AI-driven peak integration
• Sustainability features: Ecology mode reduces electricity consumption (~31%); supports reduced solvent/gas/electricity usage when paired with Nexera UHPLC
• Primary applications: PFAS analysis, food safety, clinical, pharmaceutical quantitative LC-MS/MS