Mass spectrometer Orbitrap™ Astral™

orbitrapMSfor the pharmaceutical industry

Product overview
Realize a universe of possibilities with the Thermo Scientific™ Orbitrap™ Astral™ Zoom mass spectrometer, delivering increased flexibility, faster throughput, deeper coverage, higher sensitivity, and accurate quantitation. Designed for next‑generation proteomics, metabolomics, lipidomics and biopharma research, the system combines fast scan rates, improved duty cycle, sub‑cellular sensitivity and novel acquisition modes to support high‑throughput discovery and clinical research workflows.

Upgraded instrument architecture
An upgraded architecture leverages parallelized high‑resolution accurate mass acquisition using Orbitrap and Astral analyzers to enable enhanced performance across applications.

Faster throughput

• Identify over 8,000 proteins from 300 samples per day

Deeper coverage

• Identify over 200,000 unique peptides from a single‑shot experiment in under 1 hour
• Comprehensively characterize small molecule samples with fragmentation of over 90% of compounds in a single injection using data‑dependent acquisition

Higher sensitivity

• Identify over 5,500 proteins from a single cell at a throughput of 50 samples per day

Accurate and Precise Quantitation

• Achieve a linear dynamic range of 6 orders of magnitude for metabolites using simultaneous quantitation and discovery (SQUAD) workflows
• Increase multiplexing with TMT HR mode to support TMTpro 35plex labeling experiments

Increased Flexibility

• Perform rapid intact, top‑down and middle‑down measurements with the BioPharma option, enabling improved pressure regulation, an extended Orbitrap analyzer scan range up to m/z 8,000, and top‑down/middle‑down MS2 measurements with the Astral analyzer
• Leverage faster stepped collision energy to increase spectral quality at speed for applications such as N‑linked glycoproteomics and metabolomics

Available configurations
Catalog Number | Model | Mass Range
BRE725700 | Orbitrap Astral Zoom Mass Spectrometer | 40 to 6000 m/z
BRE725770 | BioPharma option for Orbitrap Astral Zoom Mass Spectrometer | 40 to 8000 m/z

Product features / Technical specifications

• Dimensions (D x W x H): 185 x 96 x 140 cm
• Dynamic Range: 5 orders of magnitude intrascan dynamic range
• Mass Accuracy: <3 ppm RMS with external calibration, <1 ppm RMS with internal calibration
• Model: Orbitrap Astral Zoom Mass Spectrometer
• Scan Rates: Up to 270 Hz
• Weight (Metric): 680 kg
• Mass Range: 40 to 6000 m/z (optionally up to 40 to 8000 m/z with BioPharma option)
• Max. Resolution: Up to 480,000 at 200 m/z
• Type: Orbitrap Astral LC‑MS
• Unit Size: Each