Mass spectrometer Orbitrap™ Ascend Editions Tribrid™

ion traporbitrapMS

Brief summary
The Thermo Scientific™ Orbitrap™ Ascend Tribrid™ mass spectrometer extends capabilities for proteomics and native protein analysis with configurable mass range and advanced ion routing.

Overview
The Orbitrap Ascend Tribrid MS delivers expanded functionality for multiplexed proteomics and characterization of native protein assemblies. The platform integrates dual ion‑routing multipoles for increased scan speed and sensitivity, an optional extended mass range up to 16,000 m/z for large biomolecules, and an Auto‑Ready ion source to minimize instrument setup time. With MSn capabilities and optimized workflows, the system supports high‑coverage analyses across single‑cell proteomics, high‑throughput studies, complex protein mixtures and biopharmaceutical characterization.

Highlighted options and features

• Optional extended mass range up to 16,000 m/z for macromolecule analysis and new modalities
• Dual IRM (ion‑routing multipoles) to increase scan speed and sensitivity
• Auto‑Ready ion source to reduce setup time with dedicated automatic tuning
• Real‑time library searching for higher‑confidence peptide and small‑molecule identifications using MSn data
• Thermo Scientific AcquireX workflows for enhanced small‑molecule coverage
• Optional UVPD for improved fragmentation in Top‑Down proteomics, oligonucleotides and lipidomics
• Optional PTCR to support additional proteoform analysis
• Optional Easy‑ETD for improved fragmentation of charged precursors including PTMs
• Optional EASY‑IC ion source for internal calibration delivering mass accuracy < 1 ppm
• Control software with optimized, prebuilt method templates for diverse applications

Available models (Catalogue number | Model)
Catalogue number | Model
B51003849 | Orbitrap Ascend BioPharma Tribrid MS
FSN06-10000 | Orbitrap Ascend Tribrid MS
B51003847 | Orbitrap Ascend MultiOmics Tribrid MS
B51003848 | Orbitrap Ascend Structural Biology Tribrid MS

Characteristics / technical specifications

• Dimensions (L x W x H): 34 x 50 x 28 in. (81 x 127 x 70 cm)
• Dynamic range: > 5000 within a single scan
• Mass accuracy: < 3 ppm RMS using external calibration
• Model example: Orbitrap Ascend BioPharma Tribrid MS
• Polarity switching: One full experimental cycle acquired in < 1.1 seconds
• Scan rates: Up to 45 Hz
• Weight (metric): 181 kg (400 lb)
• Mass range: 40 to 6000 m/z — optional extended range to 16,000 m/z
• Max. resolution: Up to 480,000 at m/z 200
• Type: LC‑MS Orbitrap
• Unit size: Each