Spectrometer detector Orbitrap Exploris™ MX

massfor the pharmaceutical industrylaboratory

Short description
Monitor critical product quality attributes across late‑stage drug development and manufacturing with the Thermo Scientific™ Orbitrap Exploris™ MX mass detector. Designed for routine high‑resolution accurate‑mass (HRAM) monitoring in biopharmaceutical QC and analytical labs, the system supports sequence confirmation, peptide monitoring, intact protein analysis, glycan profiling and oligonucleotide impurity mass confirmation.

Simplicity for scientists and technicians
Chromeleon™ CDS provides built‑in methods, instrument control, automated data processing and secure data management to reduce manual intervention and minimize errors. Smart workflows and templates accelerate method setup and ensure reproducible mass monitoring.

Productivity to accelerate commercialization
High instrument uptime and rapid 'set and forget' calibration deliver consistent mass stability (one‑point calibration: <3 ppm RMS drift ≥4 weeks under prescribed conditions). Instrument status monitoring and optimized pressure control reduce unplanned downtime and repeat analyses.

Compliance for competitive advantage
Chromeleon™ CDS is scalable and designed for data integrity, traceability and regulatory compliance to support global QC workflows and audits.

Consistent results deliver confidence
Industry‑proven Orbitrap technology provides robust, reproducible performance across systems and sites for high‑confidence decision making in regulated environments.

Seamless method transfer for MAM
Efficient transfer of multi‑attribute method (MAM) assays from development to manufacturing helps bridge development and QC, enabling consistent attribute monitoring across the product lifecycle.

Dedicated global support
Local MAM specialists provide installation, training and service. Standardized System Evaluation Test (SET) and IQ/OQ protocols verify performance with comprehensive acceptance criteria.

Product variants
Catalog Number | Type
BRE725536 | Orbitrap LC-MS

Related Content

• MAM 2.0 Workflow
• Orbitrap Exploris MX Brochure
• Orbitrap Exploris MX Specifications Sheet

Related Products

• Orbitrap Exploris 240 Mass Spectrometer
• Vanquish Flex UHPLC System
• Chromeleon CDS
• BioPharma Finder Software

Scientific Resources (selected)

• Application Note: Assessing key attributes of adeno‑associated viral proteins using HPLC‑FLD‑intact mass analysis
• Application Note: The MAM 2.0 Workflow Enables Seamless Transition from Research and Development to Quality Control
• Application Note: An integrated LC‑MS System Performance Evaluation Test for Peptide Mapping and Monitoring

Technical specifications

• ACT Label: Yes
• Description: Orbitrap Exploris MX mass detector
• Dynamic Range: >5000 within a single Orbitrap mass analyzer spectrum
• Mass Accuracy: External calibration: <3 ppm RMS drift over 24 hours; 1‑point calibration: <3 ppm RMS drift for ≥4 weeks; Internal lock mass: <1 ppm RMS drift over 24 hours; EASY‑IC: <1 ppm RMS drift for at least 5 days
• Polarity Switching: One Full Scan cycle <700 ms (≈ >1.4 Hz)
• Scan Rates: Up to 22 Hz at resolution setting 15,000
• Weight (Metric): 120 kg (265 lb.) without data system, vacuum rough pumps, and optional items
• Mass Range: 40 to 3000 m/z; Up to 8000 m/z with BioPharma Option
• Max. Resolution: Up to 180,000 at m/z 200
• Type: Orbitrap LC‑MS
• Unit Size: Each