ATX motherboard Pro WS C422-ACE

Intel® XeonDDR4 SDRAMM.2 Key M

Overview
Intel ATX LGA 2066 workstation motherboard providing PCIe 3.0 x16 slots, multi-GPU capability, robust power delivery, triple M.2 with dual M.2 heatsinks, dual U.2, dual Intel LAN and support for DDR4 ECC memory. Includes integrated ASUS server-grade management software for centralized IT tasks.

Key features

• Ready for Intel® Xeon® W workstation processors (LGA 2066)
• Three PCIe 3.0 x16 slots with lane arrangement: 3-way x16/x16/x8
• Enhanced power solution: 12+2 IR3555 power stages, ProCool II connectors, alloy chokes, durable capacitors, 8-layer PCB
• Triple M.2 (including one vertical M.2) with two integrated heatsinks; Dual U.2 (NVMe) support
• ASUS Control Center Express for remote/centralized management
• Designed and validated for 24/7 operation

Multi-GPU support
Up to 48 PCIe lanes split as 3-way x16/x16/x8 across the three PCIe x16 slots to accommodate multiple high-performance GPUs for workloads such as AI training, 3D rendering and scientific modelling.

ASUS 2-WAY VGA holder (user-friendly design)
Includes a two-way VGA holder to provide rigid support for up to two high-end graphics cards and prevent PCB bending. The holder accepts an additional system fan (up to 120 mm). Recommended maximum GPU size: up to 12.90 x 5.90 cm (length x depth).

Power delivery enhancements
Stable power delivery for high-core-count Intel Xeon W processors with features including:

• ProCool II power connector (improved EATX 8-pin with solid pin design and diagnostic LED)
• 12+2 power stages with IR3555
• Alloy chokes and thermal pads
• High-durability capacitors
• 8-layer PCB for improved power and thermal behavior

Triple M.2 & Dual U.2 — Storage and RAID
Three onboard M.2 slots (supports M.2 22110, PCIe 3.0 x4 & SATA), including one vertical slot, with dual M.2 heatsinks to reduce SSD temperatures. Two U.2 ports for NVMe devices free PCIe slots and support high-speed storage. Supports Intel VROC and RAID (0,1,5,10); VROC key required for RAID 5 and 10.

Trusted stability & reliability
Server-grade reliability with validation for continuous 24/7 operation (tested up to 45°C and 80% humidity). Mechanical reinforcements include SafeSlot PCIe and robust heatsink/heatpipe arrays for VRM and PCH cooling.

Cooling & fan controls
Comprehensive cooling controls via Fan Xpert 4 or UEFI BIOS: multiple temperature sources per header, dedicated PWM/DC pump header, auto-detection of fan type, and per-header protection (over-temperature/over-current). Auto-Tuning and Extreme Quiet modes available.

Connectivity & I/O

• Back panel: USB 3.2 Gen 2 (1×Type-C + 3×Type-A) up to 10 Gbps
• Front panel support: 4×USB 3.2 Gen1 and 4×USB 2.0
• Dual Intel Ethernet: Intel® I219-LM and Intel® I210-AT
• 6×SATA 6 Gb/s ports
• Triple M.2 (PCIe 3.0 x4 & SATA) and 2×U.2 (NVMe)

Audio
Crystal Sound 3 with Realtek® S1220A codec and Japanese audio capacitors providing 8-channel audio.

Server-grade IT management
ASUS Control Center Express provides centralized IT management for asset tracking, software deployment, monitoring and remote control.

Processor, chipset & memory support
Supports Intel® Xeon® W processors (up to 18 cores) and Intel C422 chipset. Supports Intel Turbo Boost Max Technology 3.0, Hyper-Threading, Intel RST enterprise 5.0 and 4-channel DDR4 ECC memory via 8 DIMM slots (up to 512 GB, DDR4-2933 platform dependent).

Technical specifications

• Model: Pro WS C422-ACE
• Form factor: ATX (LGA 2066 socket)
• CPU support: Intel® Xeon® W processors, up to 18 cores
• Chipset: Intel® C422
• Memory: 8×DIMM, up to 512 GB, DDR4 ECC, 4-channel, up to DDR4-2933
• PCIe: 3×PCIe 3.0 x16 (3-way x16/x16/x8, up to 48 lanes)
• M.2: 3×M.2 (22110 supported; PCIe 3.0 x4 & SATA; dual M.2 heatsinks; one vertical M.2)
• U.2: 2×U.2 (NVMe)
• SATA: 6×SATA 6 Gb/s
• Power delivery: 12+2 IR3555 stages; ProCool II connectors; alloy chokes; durable capacitors; 8-layer PCB
• Storage features: Intel VROC support (VROC key required for RAID 5/10); RAID 0/1/5/10
• LAN: Dual Intel NICs (I219-LM, I210-AT)
• Audio: Realtek S1220A, Crystal Sound 3, Japanese audio capacitors, 8-channel
• USB: Rear USB 3.2 Gen2 (1×Type-C, 3×Type-A); front: 4×USB 3.2 Gen1 + 4×USB 2.0
• Cooling headers: Multiple temp sources per header; dedicated PWM/DC pump header; Fan Xpert 4 support
• Special features: SafeSlot, ASUS 2-WAY VGA holder, dual M.2 heatsinks, Pro Workstation reliability testing, ASUS Control Center Express
• Target usage: Workstation workloads — AI training, deep learning, 3D rendering, media production, CAD/BIM