silica HPLC column
XBridge Columns for High pH and Method Development
XBridge HPLC and UHPLC columns, utilizing BEH Particle Technology, are built to withstand high pH, high temperatures , and other extreme operating conditions, including volatile eluents, for a wide range of small molecule and biomolecule LC-MS analysis. These columns are available in a broad range of sorbent particles and sizes. XP Columns (2.5 µm) for rapid analytical UHPLC separations, (3.5 and 5 µm) for reliable analytical method development and OBD Prep (5 and 10 µm) for purification chromatography.
High pH stability and chemical resistance for reliability and longevity
Maximum method development flexibility
Seamless method transfer of analytical to preparative LC
HPLC and UHPLC pH Lifetime and Reliability
These HPLC and UHPLC columns offer mobile phase pH stability that is higher than any other commercially available chromatographic phase, making it ideal for method development. Unlike approaches that claim high pH resistance, the pH stability of these columns is created by utilizing proprietary surface modifications and is incorporated into the particle synthesis process.
The columns were tested under accelerated pH 10 stability test conditions against some of the most popular chromatographic phases that claim extended high pH stability. The C18 columns showed very little degradation in chromatographic performance, exceeding the performance of the best silica column by over 1000%.