The Agilent Reciprocating Holder Apparatus 7 is ideal for automatic dissolution testing of dosage forms requiring a change of media, smaller volume or more vigorous agitation. Typical products tested include extended release tablets, capsules, transdermals, osmotic pumps and arterial stents.
The standard apparatus has seven reciprocating positions for each of the six rows with 100 or 300 mL outer tubes. The holder has a stroke length of 20 mm and agitates at 5 to 40 dips per minute. Following a designated time period, the dosage form is transported from one row to the next, and can be programmed to move to a fresh row of media, up to six media changes. For an increased number of media changes or smaller volumes, a 12-position, 12-row configuration with 50 mL vessels and an operational minimum of ~25 mL is available.
Simulates the biorelevant conditions for the skin, gastrointestinal tract and tissue required for transdermal, oral drugs and implants with biorelevant temperature agitation rates and retention times.
Tests and transports a variety of samples, saving valuable bench space. Samples are automatically transported from one medium to the next without operator intervention, and can run unattended for up to six days.
Stores up to 15 programs and maintains direct control over timepoints, agitation rate, sampling rate, and movement between vessel rows, hold dip time, and drain time.
Accommodates a variety of dosage form holders.
Supports typical volume configurations of 50, 100 and 300 mL. Additional conversion kits are available that can transition the instrument to support different volumes.