Fed-batch bioreactor CelliGen 510

batchcontinuousperfusion

The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements. Gas flow • Various combinations of one, two, three or four TMFCs: 0.06  –   3 SLPM 0.3  –   15 SLPM 0.6  –   32 SLPM 1  –   64 SLPM › Air Wash System with TMFC (0  – 15 or 0  –  32 SLPM) › Overlay with TMFC (0 –  15 or 0  – 32 SLPM) › Overlay (valve only) Exhaust line › Exhaust condenser › Manual or automatic pressure control Impellers › Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired. › Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing. Provided as standard with the CelliGen 510 bioreactors. › Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing › Spinfilter – For suspension or microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste › Cell-Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures › Packed-bed – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel® Disks to provide extremely high cell densities Sensors › Single or redundant pH/DO › Redox › Foam/level