Stirred-tank bioreactor / fermentor BIOF-S

for the pharmaceutical industryfor industryautomatic

Short features

• Automatic stainless steel fermenter range BIOF-S Series — capacities 10–20,000 L (models from 5 L available)
• Full automatic control: SIP, pH, DO, stirring, temperature, pressure, gas flow, lid lifting (optional)
• 316L tank body with 304 jacket; internal polish Ra 0.4, external Ra 0.6
• Modular options: MFC auto flow control, CIP system, tank weighing, lid lifter
• Turnkey supply available including chillers, compressors and steam generators; GMP-oriented design

Overview
BIOF-S stainless steel fermenter system comprises tank body, piping and valves, air filtration, automatic temperature and speed control, online pH and DO monitoring with automatic control, automatic defoaming and feeding, PLC centralized control and host computer software. Equipment can be supplied with oil-free silent air compressors and electric steam generators. Design pressure 0.3 MPa. Standard ports and fittings include sampling, bottom discharge, viewing mirror, safety lighting, temperature/pH/DO/defoam/acid-alkali/inoculation/feed/air/seed transfer ports; sterile inlets and exhaust with steam-sterilizable filters.

Technical specifications (summary)

• Model: BIOF-S Series
• Capacity: 10–20,000 L (typical offerings; 5 L models available)
• Tank construction: body 316L SS, jacket 304 SS; SIP for tank, pipelines and filters (100–130°C)
• Mixing: top mechanical stirring with servo motor and speed governor; AD mechanical seal; multi-stage blade paddles and detachable baffles; control accuracy ±1%
• Aeration & filtration: annular bottom gas distributor; primary and 0.01 μm sterilizing filters; steam-sterilizable filter elements; max ventilation configurable up to 2 VVM
• pH control: Hamilton / Mettler high-temp glass electrode; range 2–12 pH (display 0–14); accuracy ±0.02; intelligent PID and alarms
• DO control: Hamilton / Mettler high-temp electrode; range 0–100% (display 0–200%); accuracy ±5%; PID control and PC data logging
• Temperature control: electric heating and water cooling with circulating pump; anti-dry-run and over-temp protection; PID control; cooling water +5°C to 65°C ±0.2°C; display 0–150°C ±0.1°C
• Defoaming: peristaltic pump dosing with sensitive defoam electrode; time and proportion automatic control
• Gas flow control: rotameter or optional Vogtlin MFC for automated flow control; Siemens module integration; pressure display accuracy 0.01 MPa
• Pressure detection: direct-mounted gauge and high-temp precision sensor; range 0–0.35 MPa
• Automatic feeding: segmented PID feeding (≥10 segments), feed curve analysis, data logging; configurable peristaltic pumps

Key components / Brands

• pH electrode: Hamilton / Mettler (Switzerland)
• DO electrode: Hamilton / Mettler (Switzerland)
• PLC: Siemens (Germany); Touch screen: MCGS
• Thermostatic water pump: WILO (Germany); Gearbox/motor: SEW (Germany)
• Frequency converter: BOSCH (Germany); MFC (optional): Vogtlin
• Control software: Bioreactek™ (China)
• Other fitted components: Burkert, Gemi, DK, Sanlixin, Julang (valves/actuators); Chengfeng (rotameter)

Technical data & options

• Internal polishing Ra 0.4; external Ra 0.6; argon-shielded welding
• Wetted parts AISI 316L; imported diaphragm valves for wetted valves; polished SS piping
• SIP one-click automatic sterilization covering filters, tank and pipelines; sampling/discharge manual sterilization
• Optional modules: CIP system (complete components), lid lifting with stepper motor, tank weighing module (accuracy 0.1%), MFC auto flow control
• Compliance: designed for GMP-style installations; turnkey supply options available