Parallel twin-screw extruder PROMIX-16

co-rotating twin-screwcompoundingpelletizing

Product Overview
Co-rotating parallel twin-screw extruders are widely used in plastic modification, polymer processing, and pharmaceutical applications such as hot-melt extrusion, granulation, lipid extrusion, transdermal preparations, implantable preparations, and 3D printing extrusion. As a Sino-German joint venture, Lemix provides high-quality twin-screw extruders with advanced processing technology, GMP-compliant design, on-site engineering, and validation services.

Description
Twin-screw Extruder Configuration and Continuous Extrusion Process: Extrusion technology is a recognized continuous manufacturing process in the pharmaceutical industry, integrating feeding, melting, venting, and discharging. Upstream material handling and downstream equipment are connected with the extruder to complete the production operation. A typical twin-screw extruder configuration incorporates modular process units and continuous material flow management.

Design Highlights

• CIP cleaning kit simplifies cleaning operations: insert the cleaning hose into the adapter port and flush the screw and barrel with water.
• Screw elements and barrel are detachable and can be cleaned in a washing machine.
• Barrel operating device: after disconnecting process units they can be easily disassembled using special barrel tools.
• Modular machine design enables quick assembly and disassembly.
• Heater housing with stainless steel mirror polishing treatment.

The Lemix Control System Enables
Data acquisition and status monitoring of field-level pharmaceutical machinery and production lines. The system provides comprehensive user authority management and security strategies, including:

• Audit trail
• Electronic signature
• Recipe management and batch record reporting
• Recordable and traceable entire operation process
• Encrypted, tamper-proof database files in a proprietary format
• All data modifications logged
• Historical data backed up locally and remotely to ensure data integrity and security

Applications

• Hot Melt Extrusion (HME): Process for dispersing APIs into polymers (e.g., PVP, methacrylates, cellulose-based carriers). PROMIX equipment homogenizes materials and applies high shear to disperse the drug at molecular level; extrudate is cooled and solidified. HME enables improved dissolution and bioavailability for poorly soluble drugs (Class II and IV).
• Solid Lipid Extrusion: Cold extrusion using lipid matrices to produce plastic masses. Suitable for thermosensitive APIs due to low melting points; no additional solvents required.
• Granulation: Continuous twin-screw granulation for wet extrusion, wet granulation and melt granulation. Enables efficient agglomeration, extrusion through dies for spheronization (pellets) or direct granules; mixing intensity adjustable to produce pellets with various properties.
• Transdermal Preparations: HME applied to topical dosage forms including implants and transdermal patches.
• Pharmaceutical 3D Printing Process: Melt extrusion deposition after mixing API and excipients to form printed structures.

Technical specifications (overview table)
Model | PROMIX-11 | PROMIX-16 | PROMIX-26S | PROMIX-32S | PROMIX-40S | PROMIX-50S
Diameter | 11mm | 16mm | 25.7mm | 31.8mm | 40.3mm | 50.3mm
Barrel Length | 460mm | 670mm | 1000mm | 1260mm | 1620mm | 1980mm
L/D | 40:1 | 40:1 | 40:1 | 40:1 | 40:1 | 40:1
Motor Power | 2kw | 3.5kw | 37kw | 83kw | 110kw | 130kw
Max. Screw Speed | 1000rpm | 1000rpm | 900rpm | 900rpm | 900rpm | 900rpm
N.m Per Shaft | 6N.m | 9.5N.m | 140N.m | 315N.m | 600N.m | 980N.m
Specific Torque | 11 | 13 | 15 | 15 | 15 | 15
L*W*H | 1200x750x1300 | 1200x780x1300 | 2600x740x1680 | 3800x760x1950 | 4050x780x1300 | 4500x800x1680
Weight | 270kg | 305kg | 1500kg | - | - | -
Output | 0.2-2.5kg/h | 0.5-20kg/h | 50-200kg/h | 60-250kg/h | 80-300kg/h | 100-350kg/h

characteristics / technical specifications

• Model: PROMIX-16
• Diameter: 16 mm
• Barrel Length: 670 mm
• L/D: 40:1
• Motor Power: 3.5 kW
• Max. Screw Speed: 1000 rpm
• N.m per Shaft: 9.5 N.m
• Specific Torque: 13
• Dimensions (L×W×H): 1200 × 780 × 1300 mm
• Weight: 305 kg
• Output Capacity: 0.5–20 kg/h