Twin screw extruder PROMIX-11

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Overview
PROMIX-11 is a lab-scale 11 mm twin-screw hot-melt extruder designed for small-batch trials, formulation development, material screening and early-stage process research in pharmaceutical R&D. It enables evaluation of feeding behavior, melting and dispersion performance, screw configuration, torque response, venting and pellet quality with low material consumption.

Twin-screw Extruder Configuration
Extrusion is a continuous manufacturing process broadly used in the pharmaceutical sector, integrating feeding, melting, venting and discharge. Upstream material handling and downstream processing equipment can be connected to the extruder to complete a continuous production line.

Design Highlights
CIP-compatible cleaning kit simplifies maintenance: insert the cleaning hose into the adapter port to flush screw and barrel. Screw elements and barrel sections are detachable for cleaning and can be washed separately.

Barrel and Mechanical Features
Process units are removable using dedicated barrel tools for rapid disassembly. The modular machine concept facilitates quick assembly and service. Heater housings receive stainless-steel mirror polishing for ease of cleaning.

Lemix Control System

• Data acquisition and real-time monitoring of pharmaceutical field devices and production lines
• Granular user access control and security policies
• Audit trail and electronic signature support
• Recipe management and batch record reporting
• Full operation process recording and traceability
• Encrypted, tamper-evident database files in proprietary format
• Comprehensive logging of data modifications
• Local and remote historical data backup to ensure data integrity

Applications
Hot Melt Extrusion (HME)
Process for dispersing APIs into polymer carriers: PROMIX equipment homogenizes formulations while high shear disperses actives at the molecular level to form solid dispersions, improving dissolution and bioavailability.

Solid Lipid Extrusion
Cold extrusion of lipid-based matrices to produce plastic masses suitable for thermosensitive APIs without additional solvents.

Granulation
Continuous twin-screw operation supports wet extrusion, wet granulation and melt granulation to produce pellets with adjustable properties; options include extrusion through dies for spheronization or granulation without dies.

Transdermal Preparations
Suitable for topical dosage forms including implants and transdermal patches.

Pharmaceutical 3D Printing
API–excipient blends processed by melt extrusion deposition for additive manufacturing of dosage forms.

Technical specifications
Model range: PROMIX-11, PROMIX-16, PROMIX-26S, PROMIX-32S, PROMIX-40S, PROMIX-50S

• Model: PROMIX-11
• Diameter: 11 mm
• Barrel Length: 460 mm
• L/D: 40:1
• Motor Power: 2 kW
• Max Screw Speed: 1000 rpm
• Torque per Shaft: 6 N·m
• Specific Torque: 11
• Dimensions (L×W×H): 1200×750×1300 mm
• Weight: 270 kg
• Output: 0.2–2.5 kg/h