Quadrupole spectrometer maXis II™

TOF-MSMS/MSfor pharmaceutical applications

Heralds a new era in accurate-mass LC-MS/MS Performance Record-breaking full sensitivity resolution (FSR) of > 80,000. High-definition Five orders of magnitude dynamic range achieved at UHPLC speeds due to 50 GBit/sec sampling technology-definitive trace analysis from complex, high-background matrices. Plug and play One-shot acquisition with triple-quadrupole sensitivity ensuring qualitative and quantitative results in one LC run with fastest time-to-success. Easy expertise Intelligent self-optimizing MS/MS routines for expert-caliber results first time and dedicated application packages. maXis II is THE market leading high-resolution LC-QTOF, leading the way in QTOF technology with unprecedented performance across wide ranging applications, to resolve the most demanding analytical challenges. A full range of specified performance parameters is delivered simultaneously. Bruker's Ultra-High Resolution QTOF (UHR) technology has reached new standard in accurate-mass LC-MS/MS. In addition, the system offers Electron-Transfer Dissociation (ETD) capabilities for sequence analysis of intact proteins including monoclonal antibody subunits. Furthermore, native state samples, including antibody drug conjugates, can be measured at these enhanced performance levels (Native Mass Spectrometry). Antibody Characterization - Intact and Subunit Analysis Enhanced resolution and mass precision - for highly precise and accurate determinations of the monoisotopic masses of both the Light and Heavy Chains of mAb's on an LC timescale for automated confirmation of product identity and detection of impurities.