Stirred-tank reactor Peptid-Synthesizer

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Overview
Buchiglas reactor solutions for Solid‑Phase Peptide Synthesis (SPPS). Manual and fully automated reactor systems are offered for scales from laboratory through pilot/kilo lab up to commercial production (5–500 L). Systems are designed for reproducible peptide assembly and compatible with cGMP production of peptide APIs.

SPPS process
SPPS assembles a peptide sequence on an insoluble resin by successive addition of protected amino acids. Buchiglas reactors are configured for both manual and automated SPPS workflows to ensure efficient solvent handling, mixing, filtration and reagent dosing across scales.

Manually operated peptide synthesizers
Manual systems feature a lowerable cylindrical glass vessel with heating jacket, dry‑running mechanical ATEX stirrers and a swing‑out filter plate. The design supports thorough mixing, rapid solvent exchange and efficient resin retention required for deprotection, coupling, washing and cleavage steps.

Key features (manual & general)

• Compliance and safety: cGMP‑compatible design and ATEX‑rated components where required.
• Materials: Highly corrosion‑resistant contact materials and borosilicate glass vessels for solvent compatibility.
• Optimized reactor design: Lowerable cylindrical glass vessel with heating jacket and optional heatable bottom plate for precise temperature control.
• Efficient mixing: Multistage mechanical stirrers (anchor, motorized or height‑adjustable) for uniform resin suspension and transfer.
• Convenient filtration: Swing‑out filter plate for easy filter cloth replacement and reliable resin retention.
• Customization: Standard configurations and fully customized solutions to match process and scale requirements.

Fully automated peptide synthesizers
Automated reactor systems enable batchwise SPPS with solvent and reagent dosing controlled by volume or weight, programmable sequences and integrated process control to maximize reproducibility and reduce operator dependency.

Automation features

• Gravimetric or volumetric dosing: Integrated load cells or flowmeters combined with precision pumps for accurate solvent and reagent delivery.
• Real‑time monitoring: Continuous monitoring of volume, weight, time, temperature and pH for in‑process control and traceability.
• Time‑controlled synthesis steps: Programmable deprotection, coupling and wash cycles to optimize yields and purity.

Examples and scales
Representative systems include small lab/pilot units (e.g., 10 L, 50 L) and larger automated reactors (e.g., 100 L and above) with options such as heating/cooling jackets, motorized anchor stirrers, lift/swing‑out designs and height‑adjustable stirrers.

Technical data
Filtration vessel: 5–500 L
Pressure: -1.0 (full vacuum on filtration vessel) to +0.5 bar
Temperature: -60 °C to +150 °C (short‑term up to 200 °C depending on configuration)

Specifications

• Scale range: 5–500 L
• Vessel type: Lowerable cylindrical glass vessel with heating jacket
• Filtration: Swing‑out filter plate for resin retention and solvent drainage
• Stirring: Dry‑running mechanical ATEX stirrers; multistage/motorized or anchor designs; height‑adjustable options
• Heating options: Heating jacket and optional heatable bottom plate
• Automation: Gravimetric (load cells) or volumetric (flowmeters) dosing; automated pumps; programmable sequences
• Monitoring & control: Real‑time monitoring of volume, weight, time, temperature and pH
• Compliance: cGMP compatibility and ATEX options
• Materials: Highly corrosion‑resistant materials suitable for repeated solvent/reagent exposure