Stirred-tank reactor chemReaktor CR

for the chemical industryfor chemicalslaboratory-scale

Overview
chemReactor CR is a pilot glass-lined reactor system for chemical process development, API synthesis, small-scale production and pilot-plant operation. The design combines a jacketed glass-lined steel lower vessel for thermal stability with a glass upper section for visual process control. The system is suitable for inert-atmosphere work, compatible with a wide range of solvents and acids and can operate under full vacuum; cryogenic execution to −90 °C is available as an option.

Key data
Reactor volumes: 15, 30, 60, 100, 160, 250 L
Pressure rating: full vacuum (−1.0 bar FV) to +0.5 bar
Temperature range: −60 °C (down to −90 °C with cryogenic option) to +200 °C
Materials (wetted): borosilicate glass 3.3, glass-lined steel; optional PTFE, PFA, tantalum

Typical applications

• Chemical synthesis and process development
• API and peptide production
• Purification, crystallization and separation
• Extraction and evaporation
• Cryogenic reactions and low-temperature chemistries
• Scale-up, pilot plant and kilo-lab production

System description
The CR reactor system is configured for batch and semi-batch operation. Typical configuration includes a jacketed glass-lined steel vessel with a glass observation section, a glass distillation overhead with buchiflex flexible ball-socket joints and a stainless-steel support frame. Components are selected for ATEX applications and for reliable vacuum distillation.

Standard package

• Jacketed glass / glass-lined steel reactor
• Multipurpose glass distillation overhead (buchiflex joints)
• Stainless-steel frame supporting flexible glass superstructure
• ATEX Zone 1 (0), CE and cGMP-capable configurations
• CIP-capable design and complete documentation

Standard options

• Reactor lift for easy opening and cleaning
• Sampling device and pH monitoring/control
• Gas introduction (nitrogen purge and active gases)
• Vacuum/exhaust piping and additional feeders/receivers
• Solid feeding systems and high-containment powder dosing
• Cryogenic vessel for −90 °C operation; special linings or Hastelloy C22
• Mixed systems with pressure reactor and vacuum distillation; IQ/OQ/PQ documentation

Detail view / Components
Reactor vessel

• Jacketed glass-lined steel bottom with glass observation section
• Available sizes: 15, 30, 60, 100, 160, 250 L
• Glass-lined impeller stirrer and glass-lined steel baffles
• Dead-volume-free drain valve

ATEX stirrer drive

• ATEX motor and adjustable transmission
• ATEX dry-running mechanical seal
• Glass-lined impeller

Glass dome / Cover

• Glass dome for smaller sizes, glass-lined steel covers for larger sizes
• Fast-action closure for addition of solids
• Multiple connection nozzles (up to 8)

Lifting / lowering device (optional)

• Mechanical/hydraulic lift for opening the vessel and simplified cleaning
• Facilitates inspection and maintenance

Distillation glass overhead

• Vertical condensers or compact K-design with spiral condensers
• Buchiflex flexible ball-socket joints for self-draining glass piping
• Feed vessel for liquid addition, distillation column and vapor duct with gauge and bursting disc
• Receiver for distillate collection and Dean–Stark phase separator

Examples / Applications in practice

• Visual process observation via glass section
• 60 L cryogenic reaction vessel on castors
• 50 L glass pilot reactor with overhead distillation
• 250 L reactor with hydraulic lift
• High-containment powder dosing and vacuum manifolds with glass valves

Technical specifications

• Available volumes: 15, 30, 60, 100, 160, 250 L
• Pressure range: −1.0 bar (full vacuum) to +0.5 bar
• Temperature range: approx. −60 °C (to −90 °C with cryo option) to +200 °C
• Primary materials: borosilicate glass 3.3, glass-lined steel; wetted options: PTFE, PFA, tantalum
• Agitation: glass-lined impeller stirrers; dead-volume-free drainage
• Distillation: buchiflex joints, vertical/spiral condensers, Dean–Stark separation
• Safety & compliance: ATEX Zone 1 (0), CE, cGMP; CIP-capable; FDA-conformant materials where applicable