UV-Vis spectrophotometer Tm

absorptionfor molecular and cellular biologyfor pharmaceutical applications

Overview
The Tm Analysis System Tm Analysis System Shimadzu is an absorbance-based instrument designed to evaluate the thermal stability (Tm) of nucleic acids, including oligonucleotide therapeutics. Integration with LabSolutions™ software supports data management and ER/ES-related regulatory workflows.

What is the Tm Analysis System
Tm analysis measures the change in absorbance (melting curve) as double-stranded nucleic acids are heated and dissociate into single strands. The melting temperature (Tm) is defined as the temperature at which the mole fractions of single- and double-stranded forms are equal. This measurement is used to assess thermal stability, verify sequence-dependent behavior and support development of oligonucleotide-based drugs.

Key features

• Absorbance-based melting-curve measurement for accurate Tm determination
• Control and data integrity via LabSolutions™ software
• Automated workflows to increase throughput and reproducibility
• Brand/approach: ANALYTICAL INTELLIGENCE

Downloads / Documents available
Brochure for the Tm Analysis System (PDF) and an application note Thermal Stability Analysis of Nucleic acid Drugs by New Tm Analysis System (PDF) are available for download.

Legal / Use
LabSolutions, TMSPC and the Analytical Intelligence logo are trademarks of Shimadzu Corporation or its affiliated companies. Excel is either a registered trademark or a trademark of Microsoft Corporation. For Research Use Only. Not for use in diagnostic procedures.

Specifications / Technical details

• Control software: LabSolutions™
• Primary application: Thermal stability (Tm) analysis of nucleic acids, including oligonucleotide therapeutics
• Measurement principle: Absorbance-based melting-curve analysis to determine Tm
• Regulatory/compliance: Software control supports ER/ES-related regulatory requirements
• Intended use: For Research Use Only (not for diagnostic procedures)