Dissolution tester PTSW-0

for medical agents

Suppository Dissolution Test Cell (Rotating Dialysis Cell) The PTSW-0 Suppository Dissolution Test Cell (Rotating Dialysis Cell) is placed into a standard USP type dissolution vessel which in turn is inserted into a standard tablet dissolution testing instrument to test the rate of dissolved active of suppositories and lipophilic carriers. The cell is immersed in the dissolution vessel. It is developed for the study of drug release from hydrophobic carrier preparations, such as suppositories. It encloses a small volume (max. 30ml) of inner fluid by means of a dialysis membrane. The cell itself rotates horizontally in a larger volume of test medium, which has the same pH as the inner volume. The sample is placed inside the inner cell. The rotating speed is reduced in by a factor of 4:1 using a gear. The active dissolves through the membrane into the outer phase and can be measured there using common detection technology like UV/VIS spectrocopy for example. It is proven that the PTSW-0 cell is a suitable tool to study factors which may influence the dissolution and absorption of controlled release formulations. • Drive shaft • Reduction gear drive • USP glass vessel • Thermometer • Agitator blade • Dialysis membrane • O-ring • Dialysis cell • Plastic insert supporting membrane The PTSW-O can be used with any Pharma Test dissolution testing instrument model PTWS 120D, PTWS 120S, PTWS 820D, PTWS 620, PTWS 1220 or PTWS D620. • Variable rotation speed, low speed settings using reduction gear • Useable with every Pharma Test PTWS