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The systems's wide flow rate range (from the 333 and 334 Pumps) allows for both semi-preparative and preparative separations. High pumping power accommodates a wide range of preparative column sizes. All injection modules feature a continuous flow path design. The system can accommodate large injection volumes with minimal sample waste and carryover. The new rinse station system incorporates a flowing jet wash and allows the use of up to two different rinse solvents.
- Low dwell volume allows fast, reproducible gradients
- Off bed collection racks allow for true large-scale fraction collection into vessels of your choice without sacrificing bed space
- Incorporate Gilson's System Organizers for stacking to conserve bench space
- Injection of up to 15 g per run depending on column dimensions
- The 30X Pump Series configured as injection pumps can inject volumes up to several liters to maximize sample loading on preparative HPLC columns
- Separate injection and collection pathways that eliminate contamination of fractions from the injection process
- The solvent valve allows for immediate access of up to five off bed solvent reservoirs
- The GX Direct Injection Module features an innovative injection port design that attaches directly to the injection valve reducing void volumes and minimizing carryover associated with calibrated connection tubing
- The GX Direct Injection Module offers various sample loop sizes providing the largest sample volume range on the market today
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Since 20 years HPLC systems from Shimadzu are well known as reliable, ease to use instruments for routine analysis providing excellent performance for various applications. The broad range of instruments is designed to exceed requirements from R&D laboratories as well as QA/QC labs, from micro up to preparative HPLC:
- Modular HPLC for maximum of flexibility LC-20A prominence series
- Compact HPLC for routine application LC-2010
- Preparative HPLC modules LC-8A
- Special system solutions - e.g. sample preparation for LC-NMR and LC-MS Co-Sense
- Ionchromatography systems - CDD-10Avp and PIA-1000
Data Processing
Beside integrators, different software packages are available for data acquisition, data processing and supporting FDA compliance requirements.
FDA and GLP/GMP requirements
Shimadzu offers support to meet requirements for work under GLP/GMP conditions as well as getting compliance to FDA 21 CFR Part 11 criteria's. Our software packages Class VP and Lab Solutions include audit trails functions for method, data and system operation, our software solution concept CLASS Agent offers support for database assisted handling of analytical data for the complete laboratory incl. electronic signatures and electronic records.
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Prominence UFLC
Ultra Fast Liquid Chromatograph
In Pursuit of Higher Speed and Uncompromised Separation
The goal of high-speed HPLC is to enhance the laboratory’s productivity. We believe that analytical data obtained from high-speed HPLC must be as reliable as the data from conventional HPLC. For example, resolution must be maintained at an excellent level in the case of 10,000 analytical runs by high-speed LC, retention time and area repeatability must be excellent for small volume sample injection, the need for replacement parts should be minimized, and the instrument must work stably.
We successfully achieved speed and separation performance levels that do not depend on high pressure, while simultaneously offering a high level of precision and expandability not available with previous fast LC systems.
The combination of Prominence UFLC and new reversed-phase columns achieves ten times higher speed compared to a conventional HPLC system. Furthermore, a high-speed sample injection mechanism significantly reduces total analytical cycle time. With this combination, Prominence UFLC offers three times higher resolution than conventional HPLC so that the possibility of analysis is increased for samples that are not sufficiently separated by conventional HPLC.
The high-precision solvent delivery unit and autosampler improve repeatability in small volume sample injections for high-speed LC, achieving and maintaining excellent repeatability during long endurance tests.
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Flexar™ - Reach for more choices in LC Analysis
PerkinElmer is revolutionizing the LC industry with its Flexar line of products and accessories-- the ultimate in HPLC and UHPLC technology. With the widest range of pump options available (from 6K psi to 10K psi to 15K psi), Flexar delivers a solution that will meet your application needs. The entire line has been completely re-designed to make your LC experience easier and faster. No detail has been overlooked, from the ergonomic design to the improved separation efficiency to the new Chromatography Data System—Chromera.
The new FX-15 offers the ultimate in UHPLC for advanced applications:
18,000 psi operation for the most demanding UHPLC application with more than 10x productivity improvement
Green productivity: mobile phase solvent consumption reduced by 10-15x
Chromera® - LC Chromatography Data System (CDS)
Get ready for instant gratification.
One click and you will see: CDS doesn’t get any easier than Chromera. Combining intuitive ease of use with powerful functionality and configurability, Chromera delivers the most streamlined way to get from the analysis you need to the information your enterprise demands.
Chromera’s patented Device Manager controls the state-of-the-art Flexar HPLC and UHPLC instruments. The extensive suite of automated tools allows you to easily visualize data and efficiently communicate results through an immediate and accessible workspace. Everything you need to get the job done quickly and easily is at your fingertips.
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Surveyor Plus HPLC System
The Surveyor Plus family of HPLC instruments is specifically optimized for the most demanding HPLC and LC/MS applications. Short cycle times, high sample capacity, low flow rate performance, and patented LightPipeTM technology have been integrated into one complete system for high-throughput sample processing environments.
The versatility of the modular design, featuring custom quaternary pumping solutions, provides flexibility for a wide variety of applications, from routine compound analysis to more complex matrices. This high-throughput system can be operated as a stand-alone HPLC or seamlessly coupled with the industry-leading Thermo Scientific mass spectrometers, providing a complete LC/MS solution.
Improve HPLC Sensitivity up to 5x with the Patented LightPipe Technology
The patented LightPipe™ technology provides up to five times the sensitivity of a conventional photo diode array detector and the integrated column oven offers exceptional chromatographic stability. Method development using the Surveyor Plus HPLC system is easily optimized because of its multiple injection modes, which include full loop, partial loop, and no waste. Several detector options increase application breadth with the capability of adding a fluorescence or a refractive index detector, which seamlessly integrate into the Surveyor Plus HPLC system. The ChromQuest Chromatography Data System (CDS) provides tools for 21 CFR Part 11 compliance requirements and complete system validation. The compilation of these innovative technologies and features provides your laboratory with the complete chromatography solution.
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Varian 940-LC Analytical to Prep HPLC
Scale Up to Superior Performance and Reliability
The Varian 940-LC high performance liquid chromatograph is a fully integrated, pre-configured and pre-tested system. A complete solution in a compact footprint, the automated Varian 940-LC meets all your analytical and preparative chromatography needs today, and into the future.
The Varian 940-LC delivers:
- High performance analytical HPLC
- Fast, easy scale-up to preparative HPLC
- Flexible configurations
- Unmatched concentration range
- Versatile detection
- Superb, practical injections and collections
- Simple, productivity-boosting software
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Whatever your priority, speed, resolution or sensitivity, the new Agilent 1200 Series, with its flexible, modular design, ensures configurations ideally suited to meet your application requirements. Building on ZORBAX column technology and novel system design your analysis time will be shortened up to 20x. Resolution can improve as much as 60%. More intuitive user interfaces will let you instantaneously control and monitor the instrument status. New choices in data analysis offer you rapid and efficient data review tools. The Agilent diagnostic software enables Intelligent Services providing more uptime, independent of the data system in use.
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The Tempo™ ht LC is a high throughput liquid chromatography system for applications such as metabolomics and drug discovery.
- Fast, accurate, and reproducible gradients.
- Simple mechanical design requires less maintenance.
- Flow rate feedback for each mobile phase maintains precise nano-scale flow rate control.
- Simple, easy-to-use software for system setup and control
Tempo™ ht LC System
The Tempo™ ht LC system is a single-channel HPLC that has been optimized for fast, high-throughput applications. The system includes binary solvent delivery for high pressure gradient mixing, microfluidic flow control (MFC) for fast, precise flow control, variable volume injection, and an integrated array-based UV absorbance detector.
Faster assays, lower running costs
The Tempo™ ht LC system provides efficient, high-speed chromatography. Low volume, high efficiency gradient mixing and innovative flow control provide fast, accurate, and reproducible gradients to rapidly analyze multiple components in complex matrices. Fast gradient change response and re-equilibration make this system ideal for high throughput applications. Rapid, precise flow adjustment and minimum dead time increase analysis speed while decreasing solvent waste, significantly reducing running costs.
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HL 459
Salient Features & Benefits
- Ideal for routine for Isocratic seperations and Quality assurance applications.
- High performance pulse free single piston pump with low dead volume diaphragm type pulse damper.
- Available in stainless & bio compatible PEEK materials.
- Single channel Analog to Digital convertor Data system controlled by software.
- An auto sampler, fraction collector, Solvent recycler can be easily added .
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The UltiMate® 3000 Rapid Separation LC (RSLC) solution combines unique hardware, software, and chemistries to meet all your separation requirements. You can achieve ultrafast separations, rapidly separate high sample loads, or enjoy high resolution with maximum peak capacity. The RSLC system is available in binary, quaternary, and x2 dual system variants [more].
The RSLC systems provide flow rates up to 5 mL/min and support pressures up to 800 bar (11,600 psi). This extensive flow/pressure footprint provides maximum application flexibility. Simply work with your column of choice in the appropriate zone for your application. RSLC covers them all.
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Features:
- A completely flexible system that is customizable for any laboratory with quality HPLC components options: binary or isocratic pump, automated or manual injector, UV/Vis, refractive index, multi-λ fluorescence, evaporative light scattering, or photodiode array detector
- Intuitive interface with Breeze 2 Software that allows for easy set-up, operation, and minimal training
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LC Mass Spectrometer: Ion Trap and Quadrupole
500-MS LC Ion Trap
By delivering excellent sensitivity over the entire mass range in full scan mode, and exceptional MS/MS and MSn capabilities, the Varian 500-MS quickly provides superior information for even the most complex sample matrices.
325-MS Triple Quadrupole
The Varian 325-MS is a robust, reliable option for many applications, including: environmental, food safety, clinical research and forensics. Designed to handle difficult small molecule analyses, it offers a choice of ionization modes and scanning techniques to ensure you obtain the information you are looking for.
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LC/MS
LC/MS single quadrupole mass analyser product family including mass directed fraction collection using prep LC/MS and web enabled software.
- LCMS 2010A Advanved
- Mass directed purification
- PsiPort™ mass directed auto-purification software
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The new Thermo Scientific LTQ Orbitrap Discovery provides access to the breakthrough Orbitrap™ technology for a wide range of labs. The robust, powerful and cost-effective system is ideally suited for general proteomics and metabolism applications, offering a superior alternative to Q-TOF systems. Featuring high resolution and excellent accurate mass capabilities, this hybrid LC-MS system achieves high throughput label-free profiling for differential expression while the MSn capability makes the instrument ideal for small molecule characterization and structural elucidation. The LTQ Orbitrap Discovery is a highly sensitive system with up to 30K resolution power and an exceptional scan rate, enabling the separation of trace level, isobaric analytes.
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Unprecedented sensitivity and value
Whether you are quantifying pharmaceutical candidates, measuring trace-level environmental or food contaminants, or confirming biomarkers, the Agilent 6400 Series Triple Quadrupole LC/MS systems offer greater sensitivity, productivity, and value than ever before. The new 6460 with Agilent Jet Stream thermal gradient focusing technology provides maximum sensitivity – breaking the femtogram barrier for many compounds. Or choose the incredible value of the 6410 with femtogram-level limits of detection, Agilent reliability, and lab-friendly ease of use.
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UltiMate UHPLC systems with MSQ Plus single quadrupole mass spectrometric detection are easy to use. The UltiMate System's Wellness technology, automatic calibration of the MS detector, and self-cleaning ion source allow for continuous routine operation without the need for frequent cleaning or maintenance. The complete system requires very little setup or fine-tuning to achieve optimum sensitivity. You no longer have to learn two software packages to operate your LC/MS system. Chromeleon® LC/MS software provides single-software method setup and instrument control, powerful UV and MS data analysis, and fully integrated reporting.
With Dionex Intelligent LC (LCi) solutions you can get more out of your LC/MS investment. Technologies such as tandem chromatography allow you to increase sample throughput up to 100%. Other advanced chromatography techniques like 2-D LC or on-line SPE-LC are also available for the UltiMate 3000 LC/MS system, allowing you to automate analyses in your laboratory like never before.
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LC Mass Spectrometer: Ion Trap and Quadrupole
500-MS LC Ion Trap
By delivering excellent sensitivity over the entire mass range in full scan mode, and exceptional MS/MS and MSn capabilities, the Varian 500-MS quickly provides superior information for even the most complex sample matrices.
325-MS Triple Quadrupole
The Varian 325-MS is a robust, reliable option for many applications, including: environmental, food safety, clinical research and forensics. Designed to handle difficult small molecule analyses, it offers a choice of ionization modes and scanning techniques to ensure you obtain the information you are looking for.
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LC/MS
LC/MS single quadrupole mass analyser product family including mass directed fraction collection using prep LC/MS and web enabled software.
- LCMS 2010A Advanved
- Mass directed purification
- PsiPort™ mass directed auto-purification software
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The new Thermo Scientific LTQ Orbitrap Discovery provides access to the breakthrough Orbitrap™ technology for a wide range of labs. The robust, powerful and cost-effective system is ideally suited for general proteomics and metabolism applications, offering a superior alternative to Q-TOF systems. Featuring high resolution and excellent accurate mass capabilities, this hybrid LC-MS system achieves high throughput label-free profiling for differential expression while the MSn capability makes the instrument ideal for small molecule characterization and structural elucidation. The LTQ Orbitrap Discovery is a highly sensitive system with up to 30K resolution power and an exceptional scan rate, enabling the separation of trace level, isobaric analytes.
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Unprecedented sensitivity and value
Whether you are quantifying pharmaceutical candidates, measuring trace-level environmental or food contaminants, or confirming biomarkers, the Agilent 6400 Series Triple Quadrupole LC/MS systems offer greater sensitivity, productivity, and value than ever before. The new 6460 with Agilent Jet Stream thermal gradient focusing technology provides maximum sensitivity – breaking the femtogram barrier for many compounds. Or choose the incredible value of the 6410 with femtogram-level limits of detection, Agilent reliability, and lab-friendly ease of use.
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UltiMate UHPLC systems with MSQ Plus single quadrupole mass spectrometric detection are easy to use. The UltiMate System's Wellness technology, automatic calibration of the MS detector, and self-cleaning ion source allow for continuous routine operation without the need for frequent cleaning or maintenance. The complete system requires very little setup or fine-tuning to achieve optimum sensitivity. You no longer have to learn two software packages to operate your LC/MS system. Chromeleon® LC/MS software provides single-software method setup and instrument control, powerful UV and MS data analysis, and fully integrated reporting.
With Dionex Intelligent LC (LCi) solutions you can get more out of your LC/MS investment. Technologies such as tandem chromatography allow you to increase sample throughput up to 100%. Other advanced chromatography techniques like 2-D LC or on-line SPE-LC are also available for the UltiMate 3000 LC/MS system, allowing you to automate analyses in your laboratory like never before.
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Low- and high-pass versions
Compact 1812 size construction ideally suited for auto insertion;3rd order Butterworth alignment;50 Ohm characteristic impedance;Less than 0.3 dB insertion loss;RoHS-compliant. 260°C compatible. Silver over copper or gold over nickel over silver terminations.Samples of all low pass filters are available in Coilcraft Designer's Kit D302
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LCR's 14000 series are hermetically sealed bulkhead mounting tubular filters constructed utilizing high quality feed-thru capacitors to achieve excellent high frequency performance.
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