Liquid chromatograph Nexera-e

two-dimensional liquidfor the food industrychemical

Overview
Comprehensive two-dimensional liquid chromatography (2D-LC) couples two orthogonal separation modes to maximize peak capacity for the analysis of highly complex samples. The Nexera-e integrates a dual-loop/dual-valve alternate switching architecture to deliver comprehensive 2D-LC workflows for research applications.

Improved resolving power compared to conventional 1D-LC
Comprehensive 2D-LC reduces the risk of co-elution seen in 1D separations by transferring fractions between orthogonal dimensions, improving resolution and qualitative/quantitative clarity for complex matrices.

Applications

• Pharmaceutical impurities analysis
• Proteolytic digests and peptide mapping
• Food and beverage extract characterization
• Natural products profiling
• Synthetic polymer characterization

Features

• Comprehensive 2D-LC architecture (dual-loop/dual-valve): Enables true orthogonal coupling of two independent separation modes to maximize overall peak capacity.
• Simultaneous positive/negative detection support: When paired with Shimadzu triple quadrupole mass spectrometers (TQMS), benefits from rapid polarity switching (~5 ms) and fast data capture (~1.5 ms) for high-speed LC‑MS in the 2nd dimension.
• Simplified 1D and 2D method setup: LabSolutions software provides streamlined parameter configuration for both 1D and comprehensive 2D analyses, reducing setup complexity.

Notes
Designed for separation and characterization of highly complex research samples across pharmaceutical, food, natural product and polymer fields. For Research Use Only. Not for use in diagnostic procedures.

Technical specifications

• Model: Nexera-e
• Technique: Comprehensive two-dimensional liquid chromatography (2D-LC)
• Design: Dual-loop / dual-valve alternate switching architecture
• Primary benefit: Maximizes peak capacity by combining two orthogonal separation modes
• Typical applications: pharmaceutical impurities, proteolytic digests, food extracts, natural products, synthetic polymers
• LC-MS compatibility: Supports high-speed 2D-LC; TQMS polarity reversal ~5 ms, data capture ~1.5 ms (with Shimadzu TQMS)
• Software: LabSolutions for simplified 1D and 2D method setup and operation
• Intended use: Research applications (not for diagnostic procedures)