High-performance liquid chromatograph Nexera lite inert

laboratoryfor pharmaceutical applicationsanalytical

Overview
Nexera lite inert is an HPLC system with a bio-inert flowline designed to eliminate corrosion risk from high-salt (halogenic) mobile phases and to minimize sample adsorption on metal surfaces. It is intended for reproducible protein and biopharmaceutical analyses, including charge-variant separations and aggregation testing, with stable long-term operation.

Features

• Corrosion prevention for reliable data — Fully bio-inert flowline prevents corrosion caused by halogenic salts in high-salt mobile phases, reducing maintenance and preserving chromatographic integrity.
• Reduced sample adsorption on metal surfaces — Inert materials and surface treatments minimize analyte–metal interactions, improving recovery and reproducibility for biological samples.
• Retention time stability via precise solvent delivery — LC-40i solvent delivery unit provides highly accurate mobile-phase flow for consistent retention times between runs.
• Real-time mobile-phase pH monitoring — pHM-40 continuously records mobile-phase pH; pH and detector chromatograms are saved in the same data file for traceability.

Downloads

• Nexera lite inert — Brochure [PDF / 1.69MB]
• Ion Chromatography Solutions for Environmental Analysis [PDF / 6.8MB]

Applications
Documents | Creation Date
Method Development for Separating Charge Variants of Antibody-Drug Conjugates by Ion-Exchange Chromatography | 2025-12-16
Determination of Disinfection By-Products in Drinking Water According to EPA Method 326.0 | 2025-11-25
Efficient Method Development for Separation of Antibody Charge Variants by Ion-Exchange Chromatography | 2025-11-25

Technical specifications

• Product type: High-performance liquid chromatography (HPLC) system
• Model name: Nexera lite inert
• Manufacturer: Shimadzu
• Corrosion resistance: Bio-inert flowline design to eliminate corrosion risk from high-salt (halogenic) mobile phases
• Surface treatment: Inert materials and coatings to reduce sample adsorption on metallic components
• Solvent delivery: LC-40i unit for high-precision mobile-phase delivery and retention time stability
• pH monitoring: pHM-40 for continuous real-time pH monitoring; pH and detector chromatograms stored in the same data file
• Primary applications: Protein and biopharmaceutical analysis, including aggregation testing and charge-variant separations