Supercritical fluid chromatograph Nexera UC Prep™

for chemical applicationsfor pharmaceutical applicationslaboratory

Overview
The Nexera™ UC Prep is a preparative supercritical fluid chromatography (SFC) system designed for preparative purification workflows. It combines the Nexera UC model's core performance with original preparative SFC technologies to increase throughput, reduce manual labour and integrate into existing laboratory workflows. The system delivers high recovery rates, flexible configurations in a compact benchtop format, and a reduced installation footprint to maximise laboratory resources.

Key features

• Unique separator and workflow technologies for higher recovery
  • LotusStream-style separator to improve recovery rates
  • SFC shortens analysis times compared with many preparative LC methods
  • Stacked injection function eliminates waiting time between runs
  • Simple post-run processing and high recovery for purification
• Solid autosamplers and online SFE integration
  • Solid autosampler capability enables direct loading of solid samples
  • Online SFE‑SFC workflows suppress peak broadening at large-volume loading
• Prep Solutions software for seamless preparative workflows
  • Method transfer and workflow integration specific to preparative operations
• Compact benchtop design
  • Benchtop footprint that fits limited‑space laboratories
  • Wide range of configurable flow rates
• Fully automated online extraction and fractionation
  • Automated extraction from solid samples and direct transfer to SFC for fractionation
  • Configurable direct fractionation into vials or 96‑well plates
• Environmental benefit
  • Using SFC reduces organic solvent consumption by approximately 94.2% compared with normal‑phase HPLC

Documents (applications and resources)
Documents | Creation Date
SFC Basic Guide [PDF] | 2025-07-29
Semi-Preparative Online SFE-SFC for Solid-State Injection and Purification [PDF] | 2025-06-03
Preparative Purification of Aroma Components Using a Supercritical Fluid chromatograph [PDF] | 2023-03-15

Technical documents
Documents | Creation Date
An Improvement in Preparative SFC Efficiency Utilizing Online SFE-SFC System as a “Solid Autosampler” [PDF] | 2023-09-27
Extraction and Fractionation of Functional Ingredients with Online SFE-SFC [PDF] | 2023-07-11
Preparative HPLC Primer [PDF] | 2021-07-08

Manuals
Documents | Creation Date
Nexera UC Prep Safety Guideline [PDF] | 2022-11-01
SFC-40P Instruction Manual - Back Pressure Regulator [PDF] | 2020-06-11
LC-40P SF Instruction Manual - Solvent Delivery Module [PDF] | 2020-06-11

Specifications

• Product family / model: Nexera UC Prep™ (preparative SFC)
• Technology: Preparative supercritical fluid chromatography (SFC) with optional online SFE (supercritical fluid extraction)
• Separator technology: LotusStream-style separator for improved recovery
• Injection: Stacked injection function for increased throughput
• Autosampler: Solid autosampler capability for solid‑state injection and increased loading capacity
• Automation: Fully automated online extraction and fractionation; direct fractionation into vials or 96‑well plates (configurable)
• Design: Compact benchtop footprint, flexible system configurations, low installation space requirement
• Performance: Suppressed peak broadening at high loading volumes; superior recovery rates for purification
• Environmental: Reduces organic solvent consumption (~94.2% reduction vs. normal‑phase HPLC)