Liquid chromatograph Co-Sense

high-performance liquidfor pharmaceutical applicationslaboratory

Overview
Automate sample pretreatment to increase throughput and reproducibility in bio-sample analysis. Co-Sense for BA integrates online sample preparation with HPLC analysis for seamless processing of blood serum, plasma and similar matrices.

Product summary
HPLC is commonly used to analyze drugs and analytes in bio-samples. Both sample pretreatment and chromatographic conditions strongly influence accuracy and sensitivity. Co-Sense for BA combines the newly developed MAYI-ODS on-line SPE column with an on-line dilution flow channel to perform automated pretreatment and transfer to HPLC analysis in a single, integrated workflow. This on-line pretreatment reduces manual handling and improves laboratory efficiency.

Key features

• Integrated online sample pretreatment directly coupled to HPLC analysis
• MAYI-ODS on-line SPE column designed for enrichment of analytes from bio-samples
• On-line dilution flow channel enabling automated dilution and matrix handling
• On-line Dilution Bypass in the sample introduction flow to flexibly route samples to the pretreatment column

Downloads
Brochure available: "Direct Analysis of Drugs in Blood Plasma using \"Co-Sense for BA\" Bio-Sample Pretreatment System" [PDF / 1.84MB].

Applications (selected documents)
Documents | Creation Date
Analysis of Polysorbate 80 in Protein Formulations Using 2D LCMS | 2015-03-03
Simultaneous determination of tryptophan, phenol, p-cresol and cholic acid in pretreated human blood | 2006-07-17
A good connection - Integrated in an online system: sample preparation and HPLC-MS analysis of biological samples | 2006-02-02

Characteristics / Technical specifications

• Product name: Co-Sense for BA
• Product type: Liquid chromatograph with online sample preparation (application-specific LC system)
• Main components: MAYI-ODS on-line SPE column; on-line dilution flow channel; dilution bypass
• Intended applications: Analysis of drugs and analytes in bio-samples (e.g., blood serum, plasma)
• Primary function: Automated, seamless sample pretreatment through to HPLC analysis to improve throughput and reduce manual labour
• Not for diagnostic use (for research use only)
• Manufacturer/Brand: Shimadzu