SFC chromatograph Nexera UC

SFEUHPLCLC

Overview
The Nexera UC is a Unified Chromatography system that integrates supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) to automate extraction and analysis of target components from solid samples. The platform supports combined screening with UHPLC and SFC and is designed for high-resolution, high-sensitivity separations with reduced organic solvent consumption.

Product description
Modular system suitable for analytical and preparative scale operation. Supports automated on-line extraction from solid matrices, transfer to SFC, and optional small-volume fraction collection (for example 1.5 mL vials and 96‑well microplates). Configurable for analytical SFC, UHPLC screening, or preparative SFC workflows.

Features

• Higher chromatographic resolution maintained at elevated flow rates for shorter analysis times.
• Single-system support for both UHPLC and SFC to facilitate method development and rapid separation comparison.
• Small-volume fractionation compatible with appropriate fraction collectors (example: 1.5 mL vials, microplate formats).
• Fully automated on-line extraction and transfer: extracts target compounds from solid samples and delivers them to SFC for separation and detection.
• Reduced environmental footprint: reported organic solvent consumption reduction of approximately 94.2% versus normal‑phase methods.

Related product lines / options

• Analytical SFC configurations optimized for high resolution and sensitivity, with optional fraction collection down to microplate formats.
• Preparative SFC configuration (Nexera UC Prep) for preparative scale separations with high recovery using LotusStream gas‑liquid separator and low internal volume back pressure regulator technology.

Applications and downloadable documents (titles)

• Nexera UC / Nexera UC Prep - Brochure
• Diversification of Separation Selectivity Using Supercritical Fluid Chromatography - Efficient Search for Optimal Separation Conditions by Combining LC and SFC (application note)
• Streamlining SFC Method Development Workflow Using LabSolutions MD (application note)

Technical documents and manuals (titles)

• Optimization of Supercritical Fluid Extraction Parameters for Vitamins D2, D3, and K1 from Pharmaceutical Preparations (technical report)
• A sustainable analytical approach for detecting extra virgin olive oil adulteration using Nexera UC (technical report)
• Oxygen heterocyclic compounds profile evaluation in cold-pressed Citrus essential oils using SFC‑PDA (technical report)
• Instruction Manual - Nexera UC Piping Kit
• Nexera UC System Guide
• SFE-30A Instruction Manual - Supercritical Fluid Extraction Unit

Technical specifications

• Brand: Shimadzu
• Model: Nexera UC
• System type: Unified Chromatography system integrating SFE and SFC; optional UHPLC compatibility/screening
• Modes supported: Analytical SFC, Preparative SFC, UHPLC screening
• Fraction collection: Supports small‑volume fractionation (example: 1.5 mL vials) and vessels down to 96‑well microtiter plates
• Separation advantage: High chromatographic resolution at higher flow rates for reduced analysis times
• Automation: Fully automated on-line extraction and transfer from solid sample extraction to SFC analysis
• Environmental performance: Reported organic solvent consumption reduction ~94.2% vs normal‑phase
• Preparative features: LotusStream gas‑liquid separator and low internal volume back pressure regulator for high recovery in preparative workflows
• Max. operating pressure: 660 bar (typical maximum)
• Max. back pressure: 400 bar (typical maximum)
• Injection volume range: 0.1 µL to 2000 µL (loop injection)
• Detectors compatible: UV, PDA/DAD, ELSD, single/triple quadrupole MS (LC‑MS, LC‑MS/MS)
• Column capacity: Up to 6 columns per oven, two ovens can be coupled (max. 12 columns)
• Sample capacity: Standard configurations: 3 plates (examples: 252 × 1 mL vials, 162 × 1.5 mL vials, 84 × 4 mL vials); optional plate changer up to 16896 samples (384‑well × 44 plates with up to 3 modules)