UHPLC chromatograph Nexera series

HPLClaboratoryprocess

Product title
Nexera series — Ultra High Performance Liquid Chromatograph (HPLC/UHPLC) by Shimadzu.

Overview
The Nexera series integrates UHPLC hardware design with digital technologies (AI, IoT, M2M) to increase laboratory productivity, reliability and process transparency. Systems are designed to minimise extra‑column dispersion, support high‑speed separations and enable centralized device monitoring and automated issue handling to reduce downtime.

Key technological elements
The series uses Nexflow technology to reduce extra‑column dispersion without changing internal tubing dimensions. Modular components and compact flow paths support high pressure operation and compatibility with a wide range of detectors and accessories for routine and demanding analyses.

Lineup

• Nexera X3
• Nexera XS
• Nexera XR
• Nexera lite

Features

• Automated support: AI- and M2M-driven monitoring for early detection and automated response to common faults.
• Workflow automation: self-diagnosis during acquisition and remote operation support to maintain throughput.
• Compact, modular design: space-efficient configuration and flexible detector/accessory integration.
• Analytical consistency: design choices to maximise reproducibility of high-quality chromatographic data.

Resources and media
Documentation available includes product brochures, application notes, manuals, webinars and demonstration videos covering system overview, maintenance best practices and troubleshooting of common LC issues.

Awards & sustainability
The series is presented alongside design awards and sustainability initiatives that document product recognition and Shimadzu's efforts to improve environmental and lifecycle performance.

Technical specifications

• Product family: Nexera series
• System type: HPLC / UHPLC
• Core enhancements: AI-assisted support, IoT / device networking, M2M communication
• Column/flow technology: Nexflow to minimise extra‑column dispersion
• Lineup models: Nexera X3, XS, XR, lite
• Pump/injection: parallel double‑piston pumps; Needle‑in‑Flow direct injection, 0.1–2000 µl
• Max. pressure (model dependent): approx. 440 / 700 / 1050 / 1300 bar
• Intended applications: routine to demanding liquid chromatography analyses