Particle detector ELSD-LTII

light scatteringevaporative light-scatteringoptical

Product type
Evaporative Light Scattering Detector (ELSD), Low-temperature ELSD-LTII

Overview
The ELSD-LTII combines a high-efficiency LED light source with enhanced digital signal processing and an optimized evaporation cell to deliver trace-level detection for HPLC and related workflows. The cell design reduces band broadening and the detector achieves reported sensitivity below 200 picograms. The detector operates by evaporating the mobile phase and measuring light scattering from the remaining dried analyte particles; it is a universal, non-spectroscopic detector providing consistent response across analyte chemistries.

Key features

• High-efficiency LED illumination
• Enhanced digital signal processing to minimize noise
• Optimized evaporation cell design to reduce band broadening
• Reported sensitivity below 200 picograms (<200 pg)
• Low-temperature evaporative operation (ELSD-LTII)
• Universal detection independent of analyte spectroscopic properties

Applications

• Drug discovery and pharmaceutical analysis
• Natural product characterization
• Combinatorial chemistry and library screening
• Food and beverage analysis
• High-throughput screening workflows

Downloads

• Shimadzu Analysis Guidebook - Pharmaceutical Analyses (brochure)

Technical specifications

• Detector type: Evaporative Light Scattering Detector (ELSD), Low-temperature ELSD-LTII
• Light source: High-efficiency LED
• Signal processing: Enhanced digital signal treatment to reduce noise
• Sensitivity: <200 picograms (reported)
• Optical system: Light-scattering detection of dried analyte particles (non-spectroscopic)
• Cell design: Optimized to reduce band broadening for improved peak shape
• Operation principle: Evaporation of mobile phase followed by light scattering measurement of dried particles
• Typical use: HPLC trace analysis, combinatorial chemistry, high-throughput screening