Automation software package LabSolutions™ MD

data acquisition and analysischromatographydata analysis

Overview
LabSolutions™ MD improves method development efficiency by applying an Analytical Quality by Design (AQbD) approach. The software automates configuration of mobile phases, columns and experimental parameters, generates experimental schedules using design-of-experiment methods, and provides data-analysis functions to plot design space and predicted chromatograms. LabSolutions™ MD supports LC detectors (UV, PDA) and single-quadrupole LC/MS detectors and is compatible with LCMS-2050, Nexera series and i-Series systems.

Key capabilities

• Analytical Quality by Design (AQbD) approach for robust method development
• Automatic generation of experimental schedules using design-of-experiment methods (e.g., Box–Behnken, central composite design)
• Data-analysis tools to plot design space and generate predicted chromatograms
• Support for UV, PDA and single-quadrupole LC/MS detectors (compatible with LCMS-2050)
• Automatic gradient optimization using a proprietary AI algorithm based on user-set resolution criteria
• Reduction of required data points through efficient experimental designs
• Automated switching between multiple mobile phases and columns; mobile-phase blending for automated preparation
• Compatibility with Nexera series and i-Series instruments
• Method Scouting Solution: different feature set; LabSolutions™ MD does not support SFC systems

Features (summarized)

• Optimization: use of Box–Behnken and central composite designs to shorten analysis time and reduce data points
• Design space: identify robust analytical conditions beyond empirical heuristics
• Automatic gradient optimization: AI-driven search for gradients meeting resolution targets
• Automated column and mobile-phase switching and blending to reduce manual intervention

Downloads

• Automation and Efficiency Improvement Solutions (HPLC and LC-MS)
• LabSolutions MD - Solution for Method Development and Analytical Quality by Design
• Effortless Method Development with LabSolutions MD
• Shim-pack Method Development Column Kit
• Method Scouting System - High Performance Liquid Chromatograph
• The Fine Art of Method Development

Applications / Example documents
Method Development for Separating Charge Variants of Antibody-Drug Conjugates by Ion-Exchange Chromatography — Creation Date: 2025-12-16
Exploration and Optimization of Efficient Separation Conditions for Oligonucleotides by Reversed-Phase Ion-Pair Chromatography — Creation Date: 2025-11-30
Investigation of Separation Conditions and Prep Purification of GLP-1 Receptor Agonist Semaglutide — Creation Date: 2025-11-25

Technical documents (examples)
Automated Gradient Optimization based on AI Algorithm for LC Method Development — Creation Date: 2023-10-09
Efficient Method Development by automated pH Screening with LabSolutions MD — Creation Date: 2023-01-05
Efficient method development based on Analytical Quality by Design with LabSolutions MD software — Creation Date: 2022-04-04

Notes / Limitations

• LabSolutions™ MD does not support SFC systems.
• Method Scouting Solution differs in capabilities; some Method Scouting functions do not create experimental designs or design spaces as LabSolutions™ MD does.

Technical specifications

• Product type: Software for HPLC/LC‑MS method development
• Approach: Analytical Quality by Design (AQbD)
• Experimental designs supported: Box–Behnken, central composite design
• Optimization: AI algorithm for automatic gradient optimization based on resolution criteria
• Data outputs: design space plotting, predicted chromatogram generation
• Detector support: UV detector, PDA detector, single-quadrupole LC/MS
• Compatibility: LCMS-2050, Nexera series, i-Series systems
• Automation: automated switching between multiple mobile phases and columns; mobile-phase blending for automated preparation
• Typical applications: method scouting, oligonucleotide separations, TAG analysis workflows, ADC charge variant separation, peptide/biopharma method development