Dry granulator GTC III

wetfor pharmaceutical applicationsfor the pharmaceutical industry

Overview
The GTC III is an integrated granulation line engineered for contained handling of highly potent active pharmaceutical ingredients (HPAPIs). Designed to OEB 5 containment standards, the system delivers a continuous granulation workflow from wet granulation through milling to final blending, with options for contained material transfer and in‑isolator weighing.

Features & benefits
Complete OEB 5 granulation line | Enables granulation through blending under high containment for HPAPIs
Rapid transfer port, active transfer port, contained poly bag transfer | Supports safe, integrity-preserving material transfers into isolators
Capacity range 1.5–10 L | Adapts to small-scale R&D and clinical batch requirements
Integrated wet and dry mills | Enables contained particle sizing across wet and dry stages
Multiple glove ports and in‑isolator scale option | Ensures operator access and closed‑system weighing where required
IPC control with 21 CFR Part 11 compliance | Provides audit trails, user/recipe management and batch reporting
Strategically placed washing nozzles and handheld options | Facilitates efficient contained cleaning
Optimised footprint | Reduces facility space requirements and eases integration

Key features (list)

• OEB 5 containment design for HPAPI processing
• Integrated wet and dry milling for contained particle sizing
• Rapid transfer port, active transfer port and contained poly bag transfer options
• Multiple glove ports for operator access inside the isolator
• Option to integrate weighing scale inside the isolator
• Online interface for binder spray rate monitoring
• IPC-based control with 21 CFR Part 11 compliance (audit trails, user/recipe management, batch reports)
• Fixed and handheld washing nozzles for contained cleaning
• Bowl/capacities covering 1.5 to 10 L
• Compact, optimised footprint for facility efficiency

Technical specifications

• Containment level: OEB 5 compliant
• Intended application: granulation of oncological, hormonal, biopharmaceutical, antiviral and other HPAPIs
• Batch capacity range: 1.5 L to 10 L
• Process flow: integrated granulation train from wet granulation to blending
• Mills: integrated wet and dry mills for contained particle sizing
• Material transfer options: rapid transfer port (RTP), active transfer port (ATP), contained poly bag transfer
• Operator access: multiple glove ports; option to place weighing scale inside isolator
• Control system: IPC-based control with 21 CFR Part 11 compliance (audit trails, user/recipe management, batch reports)
• Cleaning: strategically placed fixed and handheld washing nozzles
• Monitoring: online interface for binder spray rate control
• Design focus: containment, operator safety, product integrity, environmental protection, optimised footprint