Fluidized bed granulator FBC 250 X•ONE

wetrotorfor pharmaceutical applications

About the FBC 250 X•ONE
The FBC 250 X•ONE is a fluid-bed processor and granulator designed for industrial pharmaceutical development and production. It supports top-spray granulation, Wurster (bottom-spray) coating, rotor-based drug layering and tangential spray processes for batches up to approximately 250 L, with a contained, non-vented design that emphasises operator and environmental safety.

Applications

• Wet-mass drying
• Top-spray granulation
• Wurster (bottom-spray) coating
• Tangential-spray processes
• Hot-melt granulation
• Rotor granulation / rotor-based drug layering

Features & Benefits (summary)

• 12-bar pressure shock-resistant system with MOST™ (Maximum Operational Safety Technology) concept — prevents mechanical deformation during pressure-shock events and enables rapid production restart.
• X•ONE inflatable seals — enable safe operation at low pressures (down to ~4.5 bar).
• QASV (Quick Action Stop Valves) — containment of explosion events within ~20 milliseconds of detection.
• Customised charging, discharging and wash-in-place (WIP) systems — available for standalone units or integration in granulation trains to meet formulation and process layouts.
• ACG process control system — compliant with ATEX (Directive 2014/34/EU), GAMP 5 and 21 CFR Part 11 for secure, auditable monitoring and control.
• Patented Düsen‑Schlick nozzles developed for ACG — optimised spray performance and simplified cleaning.

Technical specifications

• Typical batch capacity: designed for batches up to ~250 L (dependent on formulation and bulk density).
• Working volume (dependent on bulk density): Top-spray granulation — Min 75 L / Max 368 L; Wurster coating — Min 23 L / Max 170 L.
• Pressure shock protection: 12-bar pressure shock-resistant system (MOST™ concept).
• Sealing: X•ONE inflatable seals (operational safety down to ~4.5 bar).
• Explosion protection: QASV quick action stop valves — containment within ~20 ms of detection.
• Configurations: Custom charging/discharging and WIP systems; standalone or granulation-train integration.
• Control & compliance: ACG process control system; ATEX 2014/34/EU, GAMP 5, 21 CFR Part 11.
• Nozzles: Patented Düsen‑Schlick nozzles developed for ACG.