Wet granulator HSM 150 X·ONE

rotorfor pharmaceutical applicationsfor the pharmaceutical industry

About the HSM 150 X·ONE
High-shear mixer granulator designed for faster processing, narrow particle-size distribution and improved content uniformity in dry mixes. Equipped with ACG process control and the MOST™ (Maximum Operator Safety Technology) containment concept. Intended for small production batches; can operate as a standalone unit or be integrated into a granulation train.

Applications

• Wet granulation
• Mixing

Key features & benefits

• Unique product bowl geometry — Maintains a roping flow regime for uniform mixing and rapid process stabilisation with linear scalability.
• Z-shaped impeller and multi-blade chopper — Ensures uniform binder distribution, optimised particle-size distribution and reduced accumulation on the product bowl.
• 12-bar pressure shock-resistant containment (MOST™) — No mechanical deformation in pressure-shock events; non-vented, fully contained design for rapid recovery and enhanced operator safety. MOST™ approved by FSA (Germany).
• Multiple charging, discharging and wash‑in‑place (WIP) options — Flexible configurations to suit formulation and process needs.
• ACG process control system — Compliant with ATEX (Directive 2014/34/EU), GAMP 5 and 21 CFR Part 11 for secure, intuitive monitoring and control.

Available models / sizes

• QUEST HSM II — 2 L, 5 L, 10 L (small scale)
• QUEST HSM III — 15 L, 30 L, 65 L (small scale)
• HSM 150 X·ONE — 45 L (min) to 120 L (max) working volume (dependent on bulk density)
• HSM 300 X·ONE — 300 L
• HSM 400 X·ONE — 400 L
• HSM 600 X·ONE — 600 L
• HSM 800 X·ONE — 800 L
• HSM 1200 X·ONE — 1,200 L
• HSM 2000 X·ONE — 2,000 L (extra large scale)

Technical specifications

• Working volume: Min 45 L — Max 120 L (dependent on bulk density)
• Pressure shock resistance: 12-bar pressure shock-resistant system; MOST™ containment concept
• Safety & compliance: MOST™ approved by FSA (Germany); ATEX compliance (Directive 2014/34/EU)
• Process control: ACG process control system; compliant with GAMP 5 and 21 CFR Part 11
• Mechanical design: Unique product bowl geometry; Z-shaped impeller and multi-blade chopper
• Containment & operation: Non-vented, fully contained design to minimise operator exposure; rapid recovery after pressure-shock events
• Utilities & maintenance: Multiple options for charging, discharging and wash‑in‑place (WIP)
• Intended use: Designed for small production batches; suitable for wet granulation and mixing; integrable into a granulation train or used standalone