Liquid chromatograph Nexera Mikros

for pharmaceutical applicationslaboratoryESI

Overview
The High Sensitivity You Expect from a Low Flow System with the Ruggedness of HPLC Covering the Complete Range from Micro to Semi-Micro. Nexera Mikros, a Shimadzu microflow LC/MS system, delivers increased sensitivity with minimal compromise to throughput and robustness. Operating at flow rates from 1 to 500 µL/min and supporting column I.D. from 0.1 to 1 mm, the system is designed for sensitive quantitative analyses in clinical and research environments while maintaining HPLC-like ruggedness.

Key features

• Improved detection limits using microflow operation
• Microflow robustness comparable to conventional HPLC systems
• Easy, familiar operation for laboratory workflows

Applications (selected documents)
Document | Creation Date
Multi-omics Analysis Using Next-Generation Sequencer and Mass Spectrometer in Longevity Research | 2024-04-22
High-Sensitivity Analysis of Drugs in Ultra-Small Volume Plasma Samples Using Microflow LC/MS/MS | 2020-10-21
High Sensitivity Identification of Drug Metabolites with Increasing Ionization Efficiency using A Novel LC-ESI Interface and Q-TOF | 2019-05-30

Technical documents / Manuals (selected)
Document | Creation Date
Guide to Biopharmaceutical Solutions | 2021-09-01
A new method for the analysis of increased D-amino acids in proteins due to aging | 2020-10-22
High-Sensitivity Analysis of Aldosterone in Low-Volume Serum Samples using Micro-Flow LC-MS/MS for Clinical Research | 2019-09-04
LC-Mikros Instruction Manual | 2025-04-23
CTO-Mikros Instruction Manual | 2018-02-22

Characteristics / Technical specifications

• Flow rate range: 1 to 500 µL/min
• Column inner diameter: 0.1 to 1 mm
• Supports micro to semi-micro LC/MS applications
• Robust microflow solvent delivery for stable quantitative performance
• Optimized ion source design to increase ionization efficiency
• UF-Link column connection for low dead-volume, stable coupling
• Improved detection limits compared with semi-micro flowrate compatible LC/MS systems (100–500 µL/min)