Mass spectrometer LCMS-8065XE

quadrupoleMS/MSfor the pharmaceutical industry

Overview
Shimadzu's LCMS-8065XE is a triple-quadrupole LC-MS/MS designed to provide high sensitivity, robustness and throughput for trace-level quantitative analysis in complex matrices. The system integrates StreamFocus electrospray ionization, IonFocus ion optics and the UFsweeper IV collision cell to improve ion transmission and reduce gas consumption and contamination-related sensitivity loss.

Key Highlights

• StreamFocus ionization to enhance ion intake and reduce droplet dispersion.
• Reduced gas consumption and optimized throughput for routine high-throughput analysis.
• Enhanced sensitivity and accuracy for reliable quantitative results at trace levels.

Core Technologies

• StreamFocus ESI probe: low-diffusion nebulizer nozzle to increase ion intake and lower nebulizer gas use.
• IonFocus unit: electrode-based ion focusing that directs target ions into the mass spectrometer while limiting neutral contaminants.
• UFsweeper IV collision cell: enlarged entrance lens and additional lenses to boost ion throughput and transmission efficiency.
• Proprietary UF technologies combining ion focusing, ESI design and collision cell improvements for ultra-fast, high-sensitivity MS/MS.

Performance, Throughput and Robustness
The LCMS-8065XE concentrates ions for trace-level detection and supports ultra-fast quantitative workflows, including PFAS analysis. Robustness tests demonstrate retention of >85% initial response after 10,000 injections of treated wastewater without LC switching valves, indicating durability in demanding matrices.

Maintenance and Usability
Designed for easy maintenance: the desolvation line (DL) and ESI capillary are replaceable; the DL can be replaced without breaking vacuum to reduce downtime. Automation functions support instrument checks and automated tuning to maintain consistent performance.

Software and Workflow Optimization

• PERFORMANCE CONCIERGE: automatic instrument checks and tuning with diagnostics to maximize uptime.
• LabSolutions Connect: automated MRM optimization and database storage of acquisition parameters to accelerate method development.
• PeakIntelligence for LCMS: AI-driven peak detection and integration to improve reproducibility and reduce manual review time, including robust integration at low signal-to-noise ratios.

Applications
Targeted quantitative workflows such as PFAS analysis (demonstrated part-per-trillion sensitivity for a 1 ng/L mixed PFAS standard), food safety, clinical and pharmaceutical quantitation, and other trace-level analyses.

Sustainability and Energy Efficiency
An ecology mode monitors system usage and can automatically shut down after inactivity periods to reduce power consumption (reported potential reduction ~31%) and lower peripheral usage when not in analysis, contributing to reduced CO2 emissions and operational costs.

Documentation
A full product brochure is available with specifications, compliance options and application highlights.

Technical specifications

• Instrument type: Triple-quadrupole LC-MS/MS
• Ionization: StreamFocus electrospray ionization (ESI) probe with low-diffusion nebulizer nozzle
• Ion optics: IonFocus unit to improve ion transmission and reduce neutral contaminants
• Collision cell: UFsweeper IV collision cell with increased entrance lens diameter and additional lenses
• Software: PERFORMANCE CONCIERGE, LabSolutions Connect, LabSolutions Insight, PeakIntelligence
• Applications: Ultra-trace PFAS analysis, food safety, clinical and pharmaceutical quantitative workflows
• Robustness: >85% initial response after 10,000 injections in challenging matrices
• Maintenance: Replaceable desolvation line and ESI capillary (DL replaceable without breaking vacuum)
• Energy efficiency: Ecology mode to reduce power consumption (approx. 31% reduction reported)