Quadrupole spectrometer LCMS-9050

TOF-MSQTOFfor the pharmaceutical industry

Overview
The LCMS-9050 is a quadrupole Time-of-Flight (Q-TOF) liquid chromatograph–mass spectrometer developed using technologies from the Shimadzu LCMS series. Integrated high-precision temperature control reduces mass drift from external factors, enabling stable accurate-mass measurements with reduced need for routine calibration. Stable high-speed positive/negative polarity switching allows near-simultaneous acquisition of positive and negative ions, expanding application scope and increasing analytical throughput. The design simplifies mass calibration, routine maintenance and non-analytical procedures, and supports a wide range of optional front-end configurations and accessories to broaden obtainable data.

Key features

• Quadrupole Time-of-Flight LC-MS architecture for accurate-mass acquisition.
• High-precision temperature control for long-term mass stability without frequent calibration.
• Fast positive/negative polarity switching for simultaneous or rapid alternate ion acquisition.
• UFstabilization™ technology to enhance stability and mass accuracy.
• Performance Assistant for simplified tuning and routine setup.
• Compatibility with multiple optional front-ends and accessories (e.g., PESI, SFC) to support diverse workflows.

Applications and advantages
The LCMS-9050 supports confident identification of challenging compounds and high-throughput screening of unknowns thanks to its Q-TOF resolution and rapid polarity switching. Typical application areas include metabolomics, lipidomics, food safety (allergen/protein analysis), pharmaceutical research (drug metabolite analysis), and untargeted/non-targeted analyses. The modular front-end options enable tailored workflows for targeted and non-targeted studies, increasing laboratory versatility and data yield.

Technical specifications

• Instrument type: Quadrupole Time-of-Flight (Q-TOF) LC–MS.
• Model: LCMS-9050.
• TOF mass range: m/z 10–40,000.
• Resolution (TOF): ~45,000 FWHM.
• Mass accuracy: < 1 ppm at m/z 622.5662 (with appropriate conditions).
• Maximum data acquisition rate: up to 100 Hz.
• Integrated high-precision temperature control and UFstabilization™ for stable mass accuracy.
• Fast positive/negative polarity switching; Performance Assistant for easy tuning.
• Support for optional front-ends and accessories (PESI, SFC, probe kits) for expanded applications.