Mass spectrometer OAD-TOF

TOF-MSQTOFMS/MS

Overview
The OAD-TOF system is a Q-TOF LCMS implementing OAD (Oxygen Attachment Dissociation), Shimadzu's proprietary fragmentation technique. It enables localization of carbon–carbon double bonds in lipids and other organic molecules. When combined with the LCMS-9050—providing high mass accuracy and fast polarity switching—it supports advanced analytical applications.

Features

• OAD fragmentation: introduction of neutral radicals in positive and negative modes
• Workflow efficiency: supports dual-polarity CID/OAD within a single LC–MS run
• Versatile applications: suitable for structural lipid analysis and related organic compound studies

Videos

• OAD-TOF system — Overview and capabilities of the OAD-TOF system coupled with LCMS-9050
• OAD-TOF system Interview with Dr.Hiroshi Tsugawa — Discussion of analytical capabilities and use cases

Downloads

• OAD RADICAL SOURCE I — Brochure (PDF)
• OAD-TOF system — Brochure (PDF)

Applications
Document | Creation Date
Rapid Structural Elucidation of Lipids Including C=C Positions Using Dual-Polarity CID/OAD in a Single LC-MS Run | 2025-11-11
Oxygen Attachment Dissociation for the Structural Characterisation of Lipids Involved in Pancreatic Cancer | 2025-07-04
OAD-MS/MS for the structural identification of double-bond positions in lipids associated with alcohol toxicity | 2025-05-15
Identification of Double Bond Positions in Butter Triacylglycerols Using DPiMS QT Kit and OAD-TOF System | 2024-02-15

Technical specifications

• Instrument type: Q-TOF LCMS
• Fragmentation technology: OAD (Oxygen Attachment Dissociation)
• Primary application: localization of C=C double bonds in lipids and related organic compounds
• Compatibility: designed to integrate with LCMS-9050 (high mass accuracy, fast polarity switching)
• Fragmentation modes: introduction of neutral radicals in positive and negative modes
• Operational capability: supports dual-polarity CID/OAD within a single LC–MS run