Liquid chromatograph DPiMS™-8060

laboratoryESI

Simple pretreatment for blood and urine samples in only 2 minutes
With the DPiMS-8060, time-consuming pretreatment steps associated with forensic samples are almost completely eliminated. Analysis can begin after only simple dilution and centrifugation. This package is intended for rapid mass screening workflows where minimal sample preparation is required.

Screening of numerous toxic substances in less than 5 minutes
This method package provides MRM simultaneous analysis methods for approximately 64 compounds for blood samples and 77 compounds for urine samples commonly encountered in forensic and clinical toxicology, including illicit drugs, narcotics, psychotropics and medical drugs.

Ready-to-use method
When used with the DPiMS-8060 for mass analysis, this method package removes the need to define analysis conditions or optimize MS parameters for each compound prior to acquisition. Simultaneous multi-compound analysis can thus be executed efficiently and reproducibly.

Support for easy quantitation from pretreatment to data processing
For each compound included in the package, calibration curve information and internal standard assignments are provided to facilitate post-run quantitation and reporting.

Easily change units for LC-MS/MS analysis
DPiMS-8060 is an optional ionization kit for LCMS-8045/8050/8060 instruments. Users can readily convert the unit to an ESI interface for LC-MS/MS analysis to verify detections or perform detailed quantitative LC-MS/MS workflows.

Software that prioritizes simplicity
PESI MS Solution is dedicated software that allows the operator to select the method, place the sample and start acquisition. After analysis, the software can generate report files indicating presence/absence of target compounds.

Compounds in the database
For blood samples (shown in red): 64 compounds. For urine samples (shown in blue): 77 compounds. Figures shown in black are for both blood and urine samples.

Abused drugs etc.
Acetyl Fentanyl
Cocaine
Dihydrocodeine
Diphenidine
Ketamine
MDA
MDMA
Methamphetamine
Morphine

Narcotics, psychotropics etc.
Alprazolam
Bromazepam
Brotizolam
Chlordiazepoxide
Clobazam
Clotiazepam
Cloxazolam
Diazepam
Desmethyldiazepam
Diphenhydramine
Estazolam
Etizolam
Fludiazepam
Flunitrazepam
Flurazepam
Haloxazolam
Lormetazepam
Medazepam
Mexazolam
Midazolam
Nimetazepam
Nitrazepam
Oxazepam
Pemoline
Prazepam
Quazepam
Temazepam
Triazolam
Zolpidem
Zopiclone

Antipsychotics etc.
Amitriptyline
Amoxapine
Blonanserin
Carpipramine
Chlorpromazine
Clocapramine
Clomipramine
Clozapine
Desipramine
Dosulepin
Duloxetine
Escitalopram
Fluvoxamine
Imipramine
Lamotrigine
Levomepromazine
Maprotiline
Mianserin
Milnacipran
Mirtazapine
Nortriptyline
Paroxetine
Perospirone
Perphenazine
Pimozide
Promethazine
Propericiazine
Quetiapine
Risperidone
Sertraline
Sulpiride
Tandospirone
Trazodone
Zotepine

Other compounds
Atropine
Bupivacaine
Carbamazepine
Colchicine
Lidocaine
Sildenafil
Tofisopam
Verdenafil

Metabolites
Desmethylclotiazepam
p-hydroxymethamphetamine
7-Aminoflunitrazepam
7-Aminonitrazepam

Cautions

• Concentrations calculated with this method package are approximate values and may differ significantly from true values depending on the samples used and the condition of the equipment. Such values should not form the basis for legal or medical decisions. For accurate quantitative values, use a quantitative method with calibration curves prepared from standard samples.
• Shimadzu provides no guarantee regarding the accuracy of information included in the database or the usefulness of information obtained using the database.
• Appropriate quality control tests should be performed with standard samples to confirm qualitative information obtained with this method package.

Application documents (examples)
Use of the DPiMS-8060 for drug analysis in plasma (quantitative analyses) — application notes available for specific quantitative workflows.

Remarks
Intended for rapid screening and mass analysis workflows; results should be confirmed by quantitative methods when used for decision-making.

Trademark notice
DPiMS is a trademark of Shimadzu Corporation.