Tandem spectrometer LCMS-8065XE

quadrupoleMS/MSmass

Overview
The LCMS-8065XE is a triple-quadrupole LC-MS/MS mass spectrometer designed for high sensitivity, high throughput and long-term operational robustness. The system combines StreamFocus ionization, IonFocus ion transmission control and the UFsweeper IV collision cell to enable trace-level detection in complex matrices with reduced nebulizer gas use and simplified maintenance.

Key value propositions

• Evolved ionization: StreamFocus ESI and optimized probe geometry to reduce droplet dispersion and increase ion intake.
• Efficient operation: High-throughput design with lower running costs and reduced nebulizer gas consumption.
• Accurate quantitation: Advanced ion optics and collision cell design for improved sensitivity and reproducibility.

Core technologies and features
The platform integrates proprietary UF technologies to improve ion transmission and acquisition speed. Components include the StreamFocus ESI probe with a low-diffusion nebulizer nozzle, the IonFocus unit to concentrate target ions and exclude neutrals, and the UFsweeper IV collision cell with an enlarged entrance lens and additional lenses to increase ion throughput.

Operational and maintenance advantages
Key service parts such as the desolvation line (DL) and ESI capillary are designed for rapid replacement; the DL can be replaced without breaking vacuum to minimize downtime and support continuous workflows.

Workflow and software integration
Automation features accelerate method development and routine analysis: LabSolutions Connect automates MRM optimization and stores optimized parameters; PERFORMANCE CONCIERGE performs automated tuning checks and diagnostics; PeakIntelligence provides AI-driven peak detection and integration to reduce manual review time.

Sensitivity, robustness and applications
The LCMS-8065XE delivers ultra-trace sensitivity for challenging matrices (examples shown at part-per-trillion levels for PFAS) and maintains robustness under heavy use (demonstrated retention of >85% initial response after 10,000 consecutive injections in complex wastewater tests). Typical applications include PFAS/environmental analysis, food safety, clinical assays and pharmaceutical quantitative workflows.

Sustainability and efficiency
An ecology mode monitors usage and reduces power to peripherals, lowering electricity consumption by about 31% and reducing overall operational footprint. Integration with Nexera UHPLC systems targets reductions in solvent, gas and electricity consumption for more sustainable high-throughput analysis.

Application documents (selection)
Documents | Creation Date
An Ultra-high Sensitivity Analysis of 29 PFAS Compounds in Drinking Water by Direct Injection — 2025-11-11
Breakthrough Sensitivity and Robustness for PFAS Analysis in Chicken Tissue for EPA Method 1633A — 2025-11-11
Breakthrough Sensitivity and Robustness for PFAS Analysis in Chicken Tissue for EPA Method 1633A (alternate) — 2025-09-02
An Ultra-high Sensitivity Analysis of 29 PFAS Compounds in Drinking Water by Direct Injection (alternate) — 2025-08-28

Video overview
A product video presents the evolved ionization, efficient operation and exact quantitation enabled by the UFMS platform and highlights streamlined workflows and fast acquisition capabilities.

Technical specifications

• Ion source: StreamFocus ESI probe with low-diffusion nebulizer nozzle to reduce droplet dispersion and nebulizer gas consumption.
• Ion transmission: IonFocus unit to concentrate target ions and exclude neutral contaminants.
• Collision cell: UFsweeper IV with larger entrance lens diameter and increased number of lenses for higher ion throughput.
• Maintenance: Replaceable desolvation line (DL) and ESI capillary; DL replacement possible without breaking vacuum.
• Automation & tuning: PERFORMANCE CONCIERGE for automatic tuning checks; automated MRM optimization via LabSolutions Connect.
• Data processing: PeakIntelligence for AI-driven peak detection and integration.
• Sustainability features: Ecology mode to reduce electricity consumption (~31% reduction reported).
• Compatibility: Designed for integration with Nexera UHPLC systems for ultra-fast, high-throughput workflows.
• Demonstrated performance: Trace-level PFAS detection (part-per-trillion examples) and long-term robustness (retains >85% response after 10,000 injections in challenging matrices).