Membrane ultra-filtration unit BIO-TFF01

for liquidsfor the food industrywater

Short description

• Designed for 0.1 m² flat membrane packs
• Precision manufacturing for laboratory TFF applications
• Compatible with membrane brands: Millipore, Sartorius, PALL, LabGeni
• Supported membrane types: Biomax, PVDF, PLC variants
• Available cut-offs: 5 kDa, 8 kDa, 10 kDa, 30 kDa, 50 kDa, 100 kDa, 300 kDa, 500 kDa; 0.2 µm option
• Optional auto control module
• SS304 frame; AISI 316L for fluid-contact parts

TFF Overview
Tangential flow filtration (TFF), or cross-flow filtration, maintains flow parallel to the membrane surface to limit cake formation and stabilize flux. TFF covers microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO) depending on target particle or molecule size. The technology is widely used in pharmaceutical, biotechnology, chemical, food & beverage and environmental applications.

System overview
The BIO-TFF01 is a compact bench-top TFF unit developed for laboratory and pilot-scale processes. It accepts box-type flat membrane packs (0.1 m²) and supports microfiltration and ultrafiltration workflows for sample clarification, concentration and diafiltration.

System applications

• Cell clarification and cell fluid filtration
• Concentration and recovery of antibodies and recombinant proteins
• Protein, peptide and nucleic acid (DNA/RNA/oligonucleotide) concentration and desalting
• Removal of small impurities from water, buffers and media; continuous diafiltration/equal-volume exchange

System features

• High recovery rates while preserving biological activity
• Stable permeate flux with reduced gel/cake layer formation
• Linear scale-up path from laboratory to larger production
• Universal stainless-steel fixture compatible with major box-type flat membrane packs; supports 1–3 membrane packs
• User-friendly integrated layout; select pump and membrane package per application
• Sanitary stainless-steel support and siphon-fed feed tank suitable for aseptic continuous operation

Stainless-steel fixture & materials

• Fixture material: AISI 316L for fluid-contact components
• Sanitary 2-in / 2-out quick-connects; internal mirror polish, external sand-blast finish
• Designed for 0.1 m² imported box-type flat membranes (brands: Millipore, Sartorius, PALL, LabGeni)

Power unit / Pump

• Peristaltic laboratory-grade pump
• Max flow: 2 L/min; max working pressure: 0.3 MPa
• Controls: start/stop, direction, speed; optional signal/control interfaces (0–5 V, 0–10 V, frequency control)

Stainless steel bracket + raw material tank

• Bracket material: AISI 316L
• Optional Sartorius outlet filter
• Siphon feeding for straightforward aseptic continuous operation
• Tank volumes available: 1 L, 2 L, 3.5 L, 5 L, 10 L (customizable)

Optional items

• Auto control module for process automation and monitoring
• Alternative membrane brands and membrane types (MF/UF)
• Higher-spec peristaltic pumps and additional control interfaces
• Extra sanitary fittings and custom tank sizes

Caractéristiques / spécifications techniques

• Model: BIO-TFF01
• SKU: BIO-TFF01
• Filtration area: 0.1 m² (flat membrane pack)
• Supported cut-offs/sizes: 5 kDa, 8 kDa, 10 kDa, 30 kDa, 50 kDa, 100 kDa, 300 kDa, 500 kDa; 0.2 µm option
• Compatible membrane materials: Biomax (modified cellulose), PVDF, PLC types
• Compatible brands: Millipore, Sartorius, PALL, LabGeni
• Fixture material (fluid-contact): AISI 316L; overall structure: SS304
• Pump: max flow 2 L/min; max pressure 0.3 MPa
• Pump control: start/stop, direction, speed; optional analog/digital interfaces
• Sanitary connections: 2 in / 2 out quick-connect
• Tank feeding: siphon-fed; typical tank volumes 1–10 L (customizable)
• Applications: protein/peptide concentration and desalting, cell clarification, antibody recovery, buffer exchange/diafiltration