Liquid filter BIOTFF-HF series

membranelaboratoryfor biopharmaceutical applications

Product description
LABGNI developed the BIOTFF-HF series of hollow fiber membrane columns for perfusion cell culture. The modules use modified polyethersulfone (mPES) hollow fibers and a polysulfone (PSU) shell to support continuous medium exchange and clarification harvesting in perfusion processes. Design and materials target aseptic operation and process integration for lab to pilot and production scales.

Product Advantages

• Low bioburden and non-cytotoxic materials
• High flow rates and filtration capacity for continuous processes
• Compatible with standard sterilization methods (steam/gamma) to meet aseptic requirements
• Wide chemical compatibility for common process buffers and reagents
• 100% integrity tested to ensure consistent performance

Operating parameters
Hollow fiber material: mPES
Shell material: PSU (polysulfone)
Potting material: Polyurethane / Epoxy Resin
Net material: Polypropylene
Maximum operating pressure: 0.2 MPa
Maximum operating temperature: 60℃
Tolerable pH range: 1–14

Component parameters
Module / Specifications: BIOTFF-HF2 | BIOTFF-HF6 | BIOTFF-HF10
Hollow Fiber Material: mPES | mPES | mPES
Pore Size / MWCO Specifications: 0.2 μm, 50 kDa | 0.2 μm, 50 kDa | 0.2 μm, 50 kDa
Module Tube Diameter (mm): 20 | 76 | 176
Number of Membrane Filaments (units): 75 | 1440 | 6720
Effective Membrane Area (m²): 0.13 | 2.5 | 11
Length (cm): 61 | 63 | 61
Inner Diameter (mm): 1.0 | 1.0 | 1.0
Reactor Size (L): 1–10 | 50–100 | 200–1000

Naming Rules
Component / specification mapping examples:
Length codes: 061 = 61 cm, 063 = 63 cm
Membrane material: E-PES (mPES)
MWCO / pore size codes: 20M = 0.2 μm ; 050 = 50 kDa
Inner diameter code: 10 = 1.0 mm
Type code: S = Steam sterilizable ; G = Gamma-irradiated

Technical specifications & typical applications

• Hollow fiber material: modified polyethersulfone (mPES)
• Shell material: polysulfone (PSU)
• Potting material: polyurethane / epoxy resin
• Net material: polypropylene
• Maximum operating pressure: 0.2 MPa
• Maximum operating temperature: 60℃
• Tolerable pH range: 1–14
• Pore size / MWCO options: 0.2 μm and 50 kDa
• Available modules: BIOTFF-HF2 (laboratory), BIOTFF-HF6 (medium-scale), BIOTFF-HF10 (large-scale)
• Effective membrane areas (examples): 0.13 m² (HF2), 2.5 m² (HF6), 11 m² (HF10)
• Typical applications: perfusion medium exchange, continuous clarification harvesting, perfusion cell culture