Bioreactor for the pharmaceutical industry RTS-1C

laboratorylaboratory-scalemultipurpose

Overview
RTS-1C is a personal bioreactor that uses the patented Reverse-Spin® mixing principle to provide mechanically driven, low-energy agitation of 50 ml single‑use falcon/Tubespin bioreactor tubes. Rotation with periodic direction change ensures efficient mixing and oxygen transfer for aerobic cultivation. An integrated near-infrared (NIR) optical system enables non‑invasive, real‑time monitoring of cell growth kinetics (optical density). Temperature control, active cooling and compact footprint support benchtop bioprocess experiments and remote monitoring via cloud-enabled software.

Key features

• Reverse-Spin® mixing in 50 ml tubes, delivering high kLa (up to ~450 h-1) for efficient aerobic cultivation
• Individually controlled unit accelerates process optimization
• Support for microaerophilic and facultative anaerobic cultures (not for strict anaerobic chambers)
• Non-invasive real-time biomass/OD monitoring enabled by the mixing principle
• NIR optical detection (850 nm) for growth-kinetics registration
• Free software for data logging, visualization and analysis in real time
• Compact, low-profile design suitable for personal/benchtop use
• Temperature control and active cooling for rapid setpoint changes and stress experiments
• Task profiling and cycling for process automation
• Cloud data storage and remote monitoring via mobile or desktop

Software features

• Real-time cell growth logging
• 3D graphical representation of OD or growth rate over time per unit
• Pause, Save/Load and report export (PDF, Excel)
• Connect up to 10 units simultaneously to one computer
• Remote monitoring (internet connection required)
• Cycling/profiling and user-defined calibration for many cell types

Typical applications

• Real-time fermentation growth kinetics
• Clone candidate screening
• Protein expression experiments
• Temperature stress and fluctuation studies
• Media screening and optimization
• Growth characterization and strain quality control
• Inhibition and toxicity testing

Technical specifications

• Measurement range: 0–10 OD (10–20 ml volume; 0–19 OD λ600 nm equivalent); 0–8 OD (20–30 ml volume; 0–15.2 OD λ600 nm equivalent)
• Measurement precision: ±0.3 OD
• Light source: NIR light diode (λ = 850 nm)
• Measurement periodicity: 1–60 readings per hour
• Culture volume: 10–30 ml
• Temperature set range: +4°C to +70°C; control range: ambient −15°C to +70°C; stability ±0.1°C
• Display: LCD
• Speed control: 50–2,000 rpm
• Max units per software: 10
• Tube type aerobic/anaerobic: 50 ml tube with membrane filter (TubeSpin® Bioreactor 50, TPP®); other equivalent 50 ml bioreactor tubes possible with rotor modification
• PC requirements (minimum): Intel/AMD CPU, 1 GB RAM, Windows 10/11, USB 2.0
• PC requirements (optimal): Intel/AMD CPU, 3 GB RAM, Windows 10/11, USB 2.0
• Dimensions (W×D×H): 130 × 212 × 200 mm; Weight: 2.2 kg
• Power input: 12 V, 5 A / 60 W; External PSU input AC 100–240 V, 50/60 Hz; output DC 12 V