Simulator for laboratory applications BRS 200i

breathingfrequencyrobotized

Product overview
The BRS 200i is a breathing simulator for in‑vitro testing of nebulisers and metered‑dose inhalers (MDIs) used with spacers/valve holding chambers (VHCs). It reproduces standard sinusoidal patterns (Ph. Eur., USP) and user-defined flow vs time profiles to measure drug delivery rate and tidal drug delivered, supporting improved in‑vitro/in‑vivo correlations (IVIVCs). The instrument covers a wide range of patient physiologies including infant and neonate volumes.

Key features

• 21 CFR Part 11 compliant
• Stores and recalls test methods
• Improved accuracy for infant and neonate volume requirements
• Extensive data output and export options
• Integration with the Vertus® III range for automated shake, fire and flow control in breath profile testing
• Automatic data backup and report printing for enhanced workflow

User interface and method handling

• Touchscreen user interface with user log-in
• Pre-defined compendial breathing pattern selection
• Custom creation and editing of breathing pattern methods (flow vs time)
• Main run screen displaying ready-to-test status and test progression

Applications
In‑vitro testing of nebulisers to Ph. Eur. 2.9.44 and USP <1601>; testing MDIs with spacers/VHCs per USP <1602>; supporting IVIVC studies for MDIs with spacers/VHCs and nebulisers (compatible with filter holders for dose uniformity and with impactor/mixing inlet configurations for APSD studies).

Specifications / technical data

• Model: BRS 200i
• Volume range: 0 to 900 mL
• Frequency: 6 – 60 bpm
• I:E ratio: Variable
• Waveforms: Sinusoidal, Square, Triangular, User-defined (flow vs time)
• Profile modes: Inhalation and/or Exhalation
• Start options: On inhalation or exhalation stroke; supports user-defined start in custom profiles
• User interface: Touchscreen with user login
• Primary uses: Nebuliser testing (Ph. Eur. 2.9.44, USP <1601>), MDI with Spacer/VHC testing (USP <1602>); support for IVIVC studies with filter holders or impactor/mixing inlet configurations