Sample holder

Overview
The Watchglass/PTFE Assembly is a laboratory transfer device designed for inhaled dissolution assessment. It facilitates the collection and transfer of size-fractionated aerosol particles to conventional tablet dissolution testers, enabling controlled in vitro dissolution studies for inhaled and nasal drug products. The design is based on a concept developed by Professor Jason McConville (College of Pharmacy, University of Texas, USA) and aligns with established OIP collection workflows.

Function and application
The assembly collects size-fractionated aerosol particles (e.g. from an Andersen Cascade Impactor, ACI) onto a watchglass surface with PTFE components, allowing recovered particulate dose fractions to be transferred into standard tablet dissolution apparatus. It is intended for dissolution testing where limited aqueous fluid and surfactant conditions are used to evaluate the dissolution performance of inhaled and nasal formulations.

Key benefits

• Enables transfer of size-fractionated aerosol deposits to conventional dissolution testers for quantitative dissolution measurement.
• Supports improved in vitro–in vivo correlation (IVIVC) and comparative studies for inhaled/nasal products.
• Compatible with established impaction collection workflows and configured for use with ACI and similar OIP collection plates.
• Based on an academic concept to support realistic inhaled dissolution method development and comparative testing.

Related products / context
The Watchglass/PTFE Assembly is part of a portfolio of inhaled dissolution solutions, including dedicated inhaled dissolution apparatus and NGI dissolution cups, providing options for different collection and dissolution workflows and method development needs.

Specifications / technical details

• Product name: Watchglass/PTFE Assembly
• Intended use: Inhaled dissolution testing of size-fractionated aerosol deposits
• Primary compatibility: Andersen Cascade Impactor (ACI) and established OIP collection configurations
• Function: Collects and enables transfer of size-fractionated particles onto a watchglass/PTFE arrangement for use in tablet dissolution testers
• Design provenance: Concept developed by Professor Jason McConville, College of Pharmacy, University of Texas
• Materials: Watchglass surface with PTFE components
• Application scope: Inhaled and nasal drug delivery dissolution studies, method development and comparative/bioequivalence assessments