OverviewTwo factors are critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and anatomically representative throat and nasal models. This IVIVC test system for inhaled and nasal products integrates patient-representative elements with standard APSD and DDU hardware to support in vitro–in vivo correlations and representative deposition assessment.
Products featured in this system- High Capacity Vacuum Pump HCP7
- Critical Flow Controller TPK 200iX
- Next Generation Impactor (NGI)
- Mixing Inlet
- Compressed Air Flow Controller
- Breathing Simulators BRS 300i
- Alberta Idealised Nasal Inlet (AINI)
- Inhalytix®+ APSD data analysis software
Related accessories- Stand for TPK
- Label Printer
Related systems / applications- APSD of nasal products (nasal sprays)
- APSD and DDU testing workflows for MDIs, DPIs, SMIs and nebulisers
Documentation & Brochures (availability noted)Product brochures and component leaflets are referenced on the system page; brochure viewer links are provided where available.
MultimediaEmbedded video: System for Improved In Vitro–In Vivo Correlations (IVIVCs) of Inhaled Drug Products, demonstrating system configuration and rationale for realistic APSD/DDU measurement.
Notes on clinical relevance- Primary objective: increase clinical relevance of APSD measurement and DDU testing by combining realistic breathing profiles with anatomical throat and nasal inlets.
- System architecture combines flow control, vacuum generation, breathing simulation, impactor stages and anatomical inlets to deliver representative deposition data.
Technical specifications- Supports DDU and APSD testing with IVIVC emphasis
- Realistic breathing profiles via BRS 300i breathing simulators
- Anatomical throat and nasal models such as Alberta Idealised Nasal Inlet (AINI)
- Flow control and critical flow regulation via TPK 200iX
- Vacuum provided by High Capacity Vacuum Pump HCP7
- Particle sizing and collection via Next Generation Impactor (NGI) and mixing inlets
- APSD analysis via Inhalytix®+ software
- Modular architecture to combine pumps, flow controllers, impactors, mixing inlets, breathing simulators and anatomical inlets