Simulator for laboratory applications BRS 300i

breathingrespiratory gasrobotized

Overview
From simple sinusoidal patterns described in Ph. Eur. and USP for nebuliser and MDI+spacer testing to complex user‑defined profiles for improved in‑vitro/in‑vivo correlations (IVIVCs), the BRS 300i is a programmable breathing simulator designed for realistic inhaler testing and precise control of breathing profiles. It offers a volume range of 0 mL–5 L, a maximum free flow rate of 240 L/min and a maximum free acceleration of 25 L/s2, making it suitable for MDIs and DPIs as well as integration in advanced IVIVC studies.

Key features

• 21 CFR Part 11 compliant
• Method storage and recall
• Powerful drive system for generating challenging breathing profiles
• Extensive data output and export options
• Seamless integration with the Vertus® III range for automated shake, fire and flow control
• Automatic data backup and report printing for improved workflow reliability

Capabilities

• Waveforms: Sinusoidal, Square, Triangular, User‑defined (flow vs time)
• Profile: Inhalation and/or Exhalation
• Start: Trigger on inhalation or exhalation stroke, or use user‑defined start (flow vs time)
• User interface: Touchscreen with user log‑in, method selection and configuration screens

Applications
Suitable for limited nebuliser testing (Ph. Eur. 2.9.44; USP <1601>) and testing MDIs with spacers/VHCs (USP <1602>). Used to support IVIVC improvement for MDIs and DPIs, including use with dose uniformity apparatus (DUSA) and with impactor plus mixing inlet configurations for APSD measurement.

Technical specifications

• Volume range: 0 mL to 5 L
• Frequency: 6 – 60 bpm
• I:E ratio: Variable
• Waveforms: Sinusoidal, Square, Triangular, User‑defined (flow vs time)
• Profile: Inhalation and/or Exhalation
• Start: On inhalation or exhalation stroke / User‑defined profiles (flow vs time)
• User interface: Touchscreen (user log‑in, method selection, customisation and run screens)
• Maximum free flow rate: 240 L/min
• Maximum free acceleration: 25 L/s2
• Uses: Limited nebuliser testing (Ph. Eur. 2.9.44; USP <1601>), testing MDIs with Spacers/VHCs (USP <1602>), improving IVIVCs for MDIs and DPIs (with DUSA for dose uniformity and with impactor + mixing inlet for APSD)