Electromagnetic test chamber

volumeanalysisfor the pharmaceutical industry

Overview
Glass Expansion Chambers are glass enclosures designed to maximise aerosolisation of nasal drug products prior to cascade impaction, enabling quantitative assessment of Fine Particle Dose (FPD) and aerodynamic particle size distribution (APSD). They are used with a cascade impactor and a high-volume expansion chamber to determine the amount of drug present in small particles or droplets, typically those <10 µm, in accordance with draft guidance.

Purpose & usage
Used together with a cascade impactor and a high-volume expansion chamber, these glass chambers facilitate reproducible aerosol/aerolisation conditions for nasal sprays and aerosols. Quantifying FPD is essential because fine droplets (<10 µm) may penetrate beyond the nasal cavity into the lower respiratory tract or lungs, affecting local and systemic exposure.

Available sizes

• 1 L chamber: maximises deposition below the top stage of the impactor (suitable for nasal aerosols)
• 2 L chamber: increases aerosolisation and impactor deposition (suitable for nasal sprays)
• 5 L chamber: provides additional volume for powerful nasal sprays to develop a full plume

Key points

• Glass construction for chemical compatibility and visual inspection
• Optimised to work with cascade impactors and high-volume expansion chambers for APSD/FPD assessment
• Designed to maximise aerosolisation appropriate to nasal product type
• Range of sizes to match different spray strengths and formulations

Technical specifications

• Product name: Glass Expansion Chamber
• Material: glass
• Sizes available: 1 L, 2 L, 5 L
• Primary application: assessment of fine particles/droplets from nasal aerosols and sprays using cascade impaction
• Designed to maximise aerosolisation and impactor deposition according to product type
• Offered to meet requirements referenced in draft guidance for nasal product APSD/FPD assessment