Flow testing system APSD

temperaturesensorlaboratory

Overview
For nebulisers, droplet evaporation on the impactor surface, exacerbated by the impactor's thermal mass, can reduce solvent content and produce artificially low APSD results, particularly for drug solutions. Cooling the impactor to approximately 5°C is recommended to minimise solvent loss. APSD testing of nebulisers typically uses a lower flow rate (15 L/min) than other OINDPs to better represent tidal-breathing conditions.

Products featured in this system

• Mouthpiece Adapter
• NGI Induction Port
• Next Generation Impactor NGI
• Internal/External Filter Holder
• BAC 100i Breath Actuation Controller
• Low Capacity Vacuum Pump LCP7
• Flow Rate Sensor FRS
• NGI Cooler™
• Inhalytix®+ APSD Data Analysis Software

Related accessories

• EnviroMate™ – Benchtop Environmental Chamber
• Temperature and Relative Humidity Sensor
• Footswitch
• NGI Cup Rack
• NGI Carrying/Washing Rack
• DFM 2000 Flow Meter
• High Capacity Vacuum Pump HCP7
• Label Printer
• NGI Cooler™ Shelf

Related systems

• DDU of Nebulisers

Related applications & testing considerations

• Use cooled impactors (~5°C) to prevent evaporation and solvent loss during APSD measurement of nebulisers
• Employ lower flow rates (15 L/min) to represent tidal breathing when testing nebulisers
• Consider realistic throat/nasal models and clinically relevant breathing profiles to ensure representative APSD data

Technical specifications

• Recommended impactor temperature: approximately 5°C (to minimise droplet evaporation)
• Recommended flow rate for nebuliser APSD testing: 15 L/min (to represent tidal breathing)
• Issue addressed: droplet evaporation causing artificially low APSD measurements for solutions
• Typical ancillary equipment: NGI Cooler (cooled impactor), induction port(s), vacuum pumps (LCP7/HCP7), flow sensors, mouthpiece adapters, filter holders, Inhalytix®+ data analysis software